30 Results for "

podocytes

" in MedChemExpress (MCE) Product Catalog:
Products (30)

30 Results for "podocytes" in MCE Product Catalog:

200
Mito-TEMPO
Mito-TEMPO
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200 Publications Verification
Cat. No.: HY-112879
CAS No.: 1334850-99-5
Purity:  99.19%
Target:  

Calcium Channel PINK1/Parkin Mitochondrial Metabolism Apoptosis Autophagy NOD-like Receptor (NLR)

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology

Mito-TEMPO is a mitochondria-targeted antioxidant. Mito-TEMPO induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. Mito-TEMPO regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. Mito-TEMPO reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. Mito-TEMPO can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
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200
MitoTEMPO hydrate
MitoTEMPO hydrate
0 Images
200 Publications Verification
Cat. No.: HY-125944
CAS No.: 1569257-94-8
Purity:  98.03%
Target:  

Mitochondrial Metabolism PINK1/Parkin NOD-like Receptor (NLR) Autophagy Calcium Channel Apoptosis

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology

MitoTEMPO hydrate is a mitochondria-targeted antioxidant . MitoTEMPO hydrate induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. MitoTEMPO hydrate regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. MitoTEMPO hydrate reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. MitoTEMPO hydrate can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
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24
EHT 1864
EHT 1864
0 Images
24 Cited Publications
Cat. No.: HY-16659
CAS No.: 754240-09-0
Target:  

Ras

Research Areas:  

Neurological Disease Cancer

EHT 1864 is an inhibitor of Rac family small GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo. EHT 1864 dependently suppresses the release of migrasomes from podocytes induced by LPS, PAN, or HG .
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10
Pyrintegrin
Pyrintegrin
0 Images
10 Cited Publications
Cat. No.: HY-13306
CAS No.: 1228445-38-2
Purity:  99.71%
Target:  

Integrin

Research Areas:  

Metabolic Disease

Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling. Pyrintegrin can be used as a podocyte-protective agent and has robustly adipogenic .
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9
11R-VIVIT
11R-VIVIT
0 Images
9 Cited Publications
Cat. No.: HY-P1430
CAS No.: 592517-80-1
Synonyms: Cell permeable NFAT inhibitor
Target:  

Nuclear Factor of activated T Cells (NFAT)

Research Areas:  

Metabolic Disease

11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy .
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9
11R-VIVIT TFA
11R-VIVIT TFA
0 Images
9 Cited Publications
Cat. No.: HY-P1430A
Synonyms: Cell permeable NFAT inhibitor TFA
Target:  

Nuclear Factor of activated T Cells (NFAT)

Research Areas:  

Metabolic Disease

11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy .
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7
Spironolactone
Spironolactone
0 Images
7 Cited Publications
Cat. No.: HY-B0561
CAS No.: 52-01-7
Synonyms: SC9420
Target:  

Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel

Research Areas:  

Cardiovascular Disease Metabolic Disease Endocrinology Cancer

Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects .
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1
AC1903
AC1903
0 Images
1 Cited Publications
Cat. No.: HY-122051
CAS No.: 831234-13-0
Purity:  99.80%
Target:  

TRP Channel

Research Areas:  

Metabolic Disease

AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model .
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1
Poricoic acid A
Poricoic acid A
0 Images
1 Cited Publications
Cat. No.: HY-N2995
CAS No.: 137551-38-3
Synonyms: Poricoic acid A(F)
Category:  

Triterpenes Terpenoids Polyporaceae Extract 500 - Internal Server Error | MedChemExpress

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