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41 Results for "

polymorphonuclear leukocyte

" in MedChemExpress (MCE) Product Catalog:

Products (41)

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JPE-1375

5 Cited Publications

Cat. No.: HY-148141

CAS No.: 1254036-23-1

Purity: 99.96%

Target:

Complement System

Research Areas:

Inflammation/Immunology

JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC₅₀=6.9 μM) and reduces TNF levels (EC₅₀=4.5 μM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases .

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Resolvin E1

3 Cited Publications

Cat. No.: HY-114041

CAS No.: 552830-51-0

Purity: 95.30%

Synonyms: RvE1

Category:

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite

Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .

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Cethromycin

2 Cited Publications

Cat. No.: HY-19655

CAS No.: 205110-48-1

Synonyms: ABT-773; Abbott-195773; A-195773

Target:

Antibiotic Bacterial Parasite TNF Receptor IFNAR Interleukin Related

Research Areas:

Infection Inflammation/Immunology

Cethromycin (ABT-773; Abbott-195773) is an orally effective ketolide antibiotic with broad-spectrum antibacterial activity. Cethromycin binds to domains II/V of the 23S rRNA of the 50S subunit, inhibiting bacterial protein synthesis. Cethromycin can accumulate in lung tissue, alveolar macrophages, epithelial lining fluid, and human polymorphonuclear leukocytes. Cethromycin exhibits potent in vitro activity against a variety of respiratory pathogens, including Mycoplasma pneumoniae. Cethromycin exhibits significant intracellular and pulmonary enrichment and anti-inflammatory effects against mycoplasma pneumonia in mouse models, improving airway obstruction and airway hyperresponsiveness. Cethromycin disrupts the apicoplast and reduces liver-stage parasite burden during the liver stage of Plasmodium berghei. Cethromycin can be used in research related to pneumonia, Staphylococcus aureus infection, gonorrhea, and malaria .

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D-Citrulline

Cat. No.: HY-W016733

CAS No.: 13594-51-9

Synonyms: H-D-Cit-OH

Target:

Endogenous Metabolite

Research Areas:

Cardiovascular Disease

D-Citrulline (H-D-Cit-OH) is a stereoisomer of L-citrulline (HY-N0391). D-Citrulline significantly attenuates polymorphonuclear leukocyte (PMN)-induced cardiac contractile dysfunction in the isolated perfused rat heart subjected to ischemia/reperfusion via a non-NO-mediated mechanism .

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