2

2 Cited Publications

Target:

Research Areas:

Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.

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1

3-Isomangostin

1 Cited Publications

Cat. No.: HY-N6845

CAS No.: 19275-46-8

Category:

Xanthones Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer

Target:

DNA/RNA Synthesis Cholinesterase (ChE) CDK Aldose Reductase Bacterial

3-Isomangostin is a flavonoid compound that acts as an inhibitor of MTH1 and acetylcholinesterase, with an IC₅₀ of 52 nM against MTH1 and IC₅₀ values of 5.75 μM and 12.96 μM against AChE and BChE, respectively. 3-Isomangostin also inhibits human aldose reductase and CDK4/Cyclin D1 with IC₅₀ values of 3.48 μM and 15.6 μM, respectively. 3-Isomangostin inhibits polyol pathway flux, competes with 8-oxo-dGTP for binding to the MTH1 active site through hydrogen bonding and hydrophobic xanthone interactions, blocks cell cycle progression, reduces cancer cell viability, and exhibits growth inhibitory effects against both normal and penicillin-resistant Staphylococcus aureus. 3-Isomangostin is used in research on Alzheimer's disease, diabetic complications, Staphylococcus aureus infections, and colon cancer .

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3-Deoxyglucosone

Cat. No.: HY-N7426

CAS No.: 4084-27-9

Synonyms: 3-Deoxy-D-glucosone

Category:

Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides

Target:

GLP Receptor

3-Deoxyglucosone (3-Deoxy-D-glucosone) is a reactive intermediate of the Maillard reaction and the polyol pathway. 3-Deoxyglucosone rapidly reacts with protein amino groups to form advanced glycation end products (AGEs), such as imidazolone, it is the most specific AGE for 3-DG. 3-Deoxyglucosone synergizes with low glucose to potentiate GLP-1 secretion and is considered as a biomarker for diabetes .

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Xylitol

Cat. No.: HY-N0538

CAS No.: 87-99-0

Synonyms: Xylite

Category:

Endogenous metabolite Disease Research Fields Saccharides Cancer Monosaccharides

Target:

Environmental Pollutants Endogenous Metabolite Bacterial Autophagy Atg7 Atg8/LC3

Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .

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APPA

Cat. No.: HY-131542

CAS No.: 100750-39-8

Target:

Aldose Reductase Apoptosis

Research Areas:

Metabolic Disease

APPA is an aldose reductase inhibitor. APPA can effectively prevent apoptosis and the symptoms of Streptozotocin (HY-13753)-induced diabetes by inhibiting the polyol pathway in rats. APPA has the potential for diabetic nephropathy (DN) research .

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Sorbinil (Standard)

Cat. No.: HY-50289R

CAS No.: 68367-52-2

Target:

Aldose Reductase

Research Areas:

Metabolic Disease

Sorbinil (Standard) is the analytical standard of Sorbinil. This product is intended for research and analytical applications. Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway .

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Xylitol-13C5

Cat. No.: HY-W768347

Synonyms: Xylite-¹³C₅

Xylitol- ¹³C₅ (Xylite- ¹³C₅) is the ¹³C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .

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CC13401

Cat. No.: HY-187119

CAS No.: 158575-73-6

Target:

Aldose Reductase

Research Areas:

Metabolic Disease

CC13401 is an aldose reductase (ALR2) inhibitor with an IC₅₀ of 41.41 μM in rats. CC13401 inhibits the NADPH-dependent reduction reaction catalyzed by ALR2. CC13401 can be used in studies on the mechanisms related to the polyol pathway and diabetic complications .

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ARI-809

Cat. No.: HY-119058

CAS No.: 463976-07-0

Synonyms: CP-744809

Target:

Aldose Reductase

Research Areas:

Metabolic Disease

ARI-809 (CP-744809) is a highly selective, orally active aldose reductase inhibitor with an IC₅₀ of 1 nM. ARI-809 blocks excessive glucose flux through the polyol pathway. ARI-809 normalizes elevated sorbitol and fructose levels in sciatic nerve tissues of diabetic rat models, inhibits sorbitol accumulation in lens tissues, and brings elevated urinary albumin excretion close to normal. ARI-809 can be used in diabetes research .

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ALR2/α-Glucosidase-IN-2

Cat. No.: HY-184330

Target:

Aldose Reductase Glycosidase

Research Areas:

Metabolic Disease

ALR2/α-Glucosidase-IN-2 is an inhibitor of α-glucosidase and aldose reductase ALR2. ALR2/α-Glucosidase-IN-2 has a K_i value of 11.68 nM against yeast α-glucosidase and a K_i value of 72.64 nM against ovine ALR2. ALR2/α-Glucosidase-IN-2 inhibits intestinal carbohydrate digestion regulatory enzymes and key enzymes in the polyol pathway. ALR2/α-Glucosidase-IN-2 can be used in diabetes-related research .

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Multi-target kinase-IN-13

Cat. No.: HY-189722

Target:

Amylases Glycosidase Aldose Reductase Free Radical Scavengers

Research Areas:

Metabolic Disease Inflammation/Immunology

Multi-target kinase-IN-13 is a multi-target enzyme inhibitor and antioxidant. Multi-target kinase-IN-13 inhibits α-amylase, α-glucosidase, and aldose reductase, with IC₅₀ values of 6.71, 4.78, and 4.04 µg/mL, respectively, thereby slowing starch digestion, reducing intestinal glucose absorption, and inhibiting the polyol pathway. Multi-target kinase-IN-13 scavenges DPPH, ABTS, and NO free radicals and exhibits antioxidant capacity and ferric reducing ability. Multi-target kinase-IN-13 can be used in studies related to diabetes and antioxidation .

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