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55 Results for "

potency enhancement

" in MedChemExpress (MCE) Product Catalog:

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HOIPIN-8

6 Publications Verification

Cat. No.: HY-122882

CAS No.: 2519537-70-1

Purity: 98.90%

Target:

E1/E2/E3 Enzyme

Research Areas:

Inflammation/Immunology

HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC₅₀ of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC .

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August 31

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Indole-3-carboxylic acid

2 Cited Publications

Cat. No.: HY-40161

CAS No.: 771-50-6

Category:

Alkaloids Human Gut Microbiota Metabolites Metabolic Disease Endogenous metabolite Disease Research Fields Indole Alkaloids

Target:

Endogenous Metabolite Bacterial

Indole-3-carboxylic acid is an orally active urinary indolic tryptophan metabolite. Indole-3-carboxylic acid is a mediator of priming against Plectosphaerella cucumerina. Indole-3-carboxylic acid enhances the anti-colorectal cancer potency of Doxorubicin (HY-15142A) by inducing cell senescence. Indole-3-carboxylic acid can be used in liver disease research .

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