3351 Results for "

processed urine samples

" in MedChemExpress (MCE) Product Catalog:
Products (3351)

3351 Results for "processed urine samples" in MCE Product Catalog:

881
Z-VAD-FMK
Z-VAD-FMK
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881 Publications Verification
Cat. No.: HY-16658B
CAS No.: 161401-82-7
Synonyms: Z-VAD(OH)-FMK
Target:  

Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)

Research Areas:  

Inflammation/Immunology Cancer

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .
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306
SYBR Green qPCR Master Mix
SYBR Green qPCR Master Mix
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306 Cited Publications
Cat. No.: HY-K0501

MCE qPCR Master Mix is provided as a simple-to-use, stabilized 2× formulation that includes all components for qPCR except sample DNA, primers and water. The 100 rxns is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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74
Dapagliflozin
Dapagliflozin
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74 Cited Publications
Cat. No.: HY-10450
CAS No.: 461432-26-8
Purity:  99.97%
Synonyms: BMS-512148
Target:  

SGLT

Research Areas:  

Metabolic Disease Cancer

Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .
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74
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
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74 Cited Publications
Cat. No.: HY-10450A
CAS No.: 960404-48-2
Purity:  99.97%
Synonyms: BMS-512148 (2S)-1,2-propanediol, hydrate
Target:  

SGLT

Research Areas:  

Metabolic Disease Cancer

Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury .
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74
CX-5461
CX-5461
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74 Cited Publications
Cat. No.: HY-13323
CAS No.: 1138549-36-6
Purity:  99.49%
Target:  

DNA/RNA Synthesis MDM-2/p53 AMPK Akt Autophagy Apoptosis Checkpoint Kinase (Chk)

Research Areas:  

Cancer

CX-5461 is a selective, orally active RNA polymerase I inhibitor. CX-5461 disrupts the formation of the SL1-rDNA complex, thereby blocking the transcription initiation of ribosomal RNA without altering the activity of RNA polymerase II, DNA replication, or protein translation processes. CX-5461 upregulates the expression of p21, MDM2, Sestrin1/2, and phosphorylated AMPKα, and reduces the level of phosphorylated Akt. CX-5461 induces G2/G2/M cell cycle arrest, Autophagy, Apoptosis, and cellular senescence, and activates CHK1, CHK2, and RPA. CX-5461 can be used in research related to osteosarcoma, cervical cancer, hematologic malignancies, high-grade serous ovarian cancer, and solid tumors .
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74
CX-5461 dihydrochloride
CX-5461 dihydrochloride
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74 Cited Publications
Cat. No.: HY-13323A
Purity:  99.41%
Target:  

DNA/RNA Synthesis MDM-2/p53 AMPK Akt Autophagy Apoptosis Checkpoint Kinase (Chk)

Research Areas:  

Cancer

CX-5461 dihydrochloride is a selective, orally active RNA polymerase I inhibitor. CX-5461 dihydrochloride disrupts the formation of the SL1-rDNA complex, thereby blocking the transcription initiation of ribosomal RNA without altering the activity of RNA polymerase II, DNA replication, or protein translation processes. CX-5461 dihydrochloride upregulates the expression of p21, MDM2, Sestrin1/2, and phosphorylated AMPKα, and reduces the level of phosphorylated Akt. CX-5461 dihydrochloride induces G2/G2/M cell cycle arrest, Autophagy, Apoptosis, and cellular senescence, and activates CHK1, CHK2, and RPA. CX-5461 dihydrochloride can be used in research related to osteosarcoma, cervical cancer, hematologic malignancies, high-grade serous ovarian cancer, and solid tumors .
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64
Ammonium chloride, AR, 99.5%
Ammonium chloride, AR, 99.5%
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64 Cited Publications
Cat. No.: HY-Y1269
CAS No.: 12125-02-9
Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor .
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64
Ammonium chloride, for cell culture
Ammonium chloride, for cell culture
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64 Cited Publications
Cat. No.: HY-Y1269C
CAS No.: 12125-02-9
Synonyms: Salmiac, for cell culture
Ammonium chloride, for cell culture (Salmiac, for cell culture) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.Ammonium chloride is also a lysosome inhibitor.
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59
Sapanisertib
Sapanisertib
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59 Cited Publications
Cat. No.: HY-13328
CAS No.: 1224844-38-5
Purity:  99.63%
Synonyms: INK-128; MLN0128; TAK-228
Target:  

mTOR Apoptosis Akt ERK CDK Ribosomal S6 Kinase (RSK) Collagen HIF/HIF Prolyl-Hydroxylase Wnt

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

Sapanisertib (INK-128; MLN0128; TAK-228) is an orally active dual mTORC1/mTORC2 inhibitor. Sapanisertib directly and simultaneously inhibits mTORC1/2 activity through competitive binding with ATP, thereby comprehensively blocking downstream processes such as protein and lipid synthesis and cytoskeletal reorganization, consequently suppressing tumor cell proliferation and promoting apoptosis. Sapanisertib is applicable to research on melanoma, ovarian cancer, pulmonary fibrosis, and hematological malignancies .
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56
Elexacaftor
Elexacaftor
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56 Cited Publications
Cat. No.: HY-111772
CAS No.: 2216712-66-0
Purity:  99.74%
Synonyms: VX-445
Target:  

CFTR Autophagy

Research Areas:  

Inflammation/Immunology

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .
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52
ATP Assay Kit
ATP Assay Kit
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52 Cited Publications
Cat. No.: HY-K0314

MCE ATP Assay Kit provides a rapid method to measure intracellular ATP. The kit is suitable for ATP determination in cells, tissue, and other biological samples.

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45
RT Master Mix for qPCR II (gDNA digester plus)
RT Master Mix for qPCR II (gDNA digester plus)
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45 Cited Publications
Cat. No.: HY-K0511A

MCE RT Master Mix for qPCR II is a convenient, ready-to-use formulation for reverse transcription and can eliminate genomic DNA (gDNA) contaminations in RNA samples. With updated reverse transcriptase, this kit can synthesize cDNA more rapidly, more specifically. The 100 rxns is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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42
Renilla-Firefly Luciferase Dual Assay Kit
Renilla-Firefly Luciferase Dual Assay Kit
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42 Cited Publications
Cat. No.: HY-K1013

MCE Renilla-Firefly Luciferase Dual Assay Kit is designed to be used for high-throughput, rapid quantitation of both Firefly and Renilla luciferases from a single sample in mammalian cell culture.

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42
SYBR Green qPCR Master Mix (No ROX)
SYBR Green qPCR Master Mix (No ROX)
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42 Cited Publications
Cat. No.: HY-K0523

MCE SYBR Green qPCR Master Mix (No ROX) is provided as a simple-to-use, stabilized 2× formulation that includes all components for qPCR except sample DNA, primers and water, in which no ROX Reference Dye is included. The 100 rxns is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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38
Coppersensor 1
Coppersensor 1
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38 Cited Publications
Cat. No.: HY-141511
CAS No.: 874748-20-6
Purity:  97.74%
Coppersensor-1 (CS1) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu + with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu +) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer, cardiovascular disorders and neurogenerative diseases .
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38
C188-9
C188-9
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38 Cited Publications
Cat. No.: HY-112288
CAS No.: 432001-19-9
Purity:  99.90%
Synonyms: TTI-101
Target:  

STAT Apoptosis DNA Methyltransferase

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

C188-9 (TTI-101) is a STAT3 inhibitor with a Kd value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia .
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37
IWP-2
IWP-2
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37 Cited Publications
Cat. No.: HY-13912
CAS No.: 686770-61-6
Purity:  99.93%
Target:  

Wnt Porcupine Casein Kinase

Research Areas:  

Cancer

IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ .
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36
Apocynin
Apocynin
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36 Cited Publications
Cat. No.: HY-N0088
CAS No.: 498-02-2
Synonyms: Acetovanillone
Category:  

Monophenols Orchidaceae Extract Ketones, Aldehydes, Acids Phenols 500 - Internal Server Error | MedChemExpress

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