17

DMH-1

17 Publications Verification

Cat. No.: HY-12273

CAS No.: 1206711-16-1

Purity: 99.93%

Target:

TGF-β Receptor Organoid Microtubule/Tubulin

Research Areas:

Cardiovascular Disease Neurological Disease

DMH-1 is a selective BMP inhibitor. DMH-1 upregulates the expression of SOX1. DMH-1 increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons .

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12

UNC0638

12 Cited Publications

Cat. No.: HY-15273

CAS No.: 1255580-76-7

Purity: 99.48%

Target:

VSV Histone Methyltransferase Autophagy Influenza Virus

Research Areas:

Infection Cancer

UNC0638, a chemical probe, selectively inhibits G9a and GLP histone methyltransferases with IC₅₀ of 15 nM and 19 nM, respectively. UNC0638 inhibits TNBC cell invasion and migration in vitro. UNC0638 is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets .

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9

SB-590885

9 Cited Publications

Cat. No.: HY-10966

CAS No.: 405554-55-4

Purity: 99.77%

Target:

Raf Apoptosis

Research Areas:

Neurological Disease Cancer

SB-590885 is a BRAF/c-Raf kinase inhibitor that selectively targets B-Raf, and it amplifies the ERK/MAPK signaling pathway in RAS-activated cells. SB-590885 effectively inhibits the malignant proliferation, transformation and tumorigenicity of oncogenic B-Raf cells; it also induces the proliferation of erythroid progenitor cells, delays their differentiation and promotes hemoglobin synthesis, thereby improving ineffective erythropoiesis and reducing apoptosis. SB-590885 exerts a synergistic effect with TGF-β inhibitors and glucocorticoids, significantly promoting the formation of erythroid colonies in cells from patients with Diamond-Blackfan anemia (DBA). SB-590885 is mainly used in relevant studies on DBA, cisplatin-induced myelosuppression-related anemia, and pan-cancers such as melanoma and colorectal cancer .

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5

Cyclosporin H

5 Cited Publications

Cat. No.: HY-P1122

CAS No.: 83602-39-5

Target:

Formyl Peptide Receptor (FPR)

Research Areas:

Infection Inflammation/Immunology

Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.

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4

ATI-2341

4 Cited Publications

Cat. No.: HY-P0172

CAS No.: 1337878-62-2

Target:

CXCR

Research Areas:

Inflammation/Immunology Endocrinology Cancer

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) .

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4

ATI-2341 TFA

4 Cited Publications

Cat. No.: HY-P0172A

Target:

CXCR

Research Areas:

Inflammation/Immunology Endocrinology Cancer

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) .

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3

Moclobemide

3 Cited Publications

Cat. No.: HY-B0534

CAS No.: 71320-77-9

Synonyms: Ro111163

Target:

Monoamine Oxidase

Research Areas:

Neurological Disease

Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC₅₀ of 6.061 μM for hMAO-A .Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

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2

INDY

2 Cited Publications

Cat. No.: HY-108476

CAS No.: 1169755-45-6

Purity: 99.32%

Target:

DYRK

Research Areas:

Cancer

INDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC₅₀s of 0.24 μM and 0.23 μM, respectively. INDY binds in the ATP pocket of the enzyme and has a K_i value of 0.18 μM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells .

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2

Burixafor hydrobromide

2 Cited Publications

Cat. No.: HY-19867A

CAS No.: 1191450-19-7

Synonyms: TG-0054 hydrobromide

Target:

CXCR

Research Areas:

Cardiovascular Disease Cancer

Burixafor (TG-0054) hydrobromide is a potent CXCR4 antagonist with a pIC₅₀ of 7.4. Burixafor hydrobromide inhibits the binding of CXCL12 to CXCR4, antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2, and blocks the downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction. Burixafor hydrobromide mobilizes CD34 ⁺ hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood. Burixafor hydrobromide can be used for research on autologous hematopoietic stem cell transplantation (ASCT) .

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2

4-tert-Octylphenol

2 Cited Publications

Cat. No.: HY-B1941

CAS No.: 140-66-9

Category:

Monophenols Neurological Disease Phenols Endogenous metabolite Disease Research Fields Endocrinology

Target:

Endogenous Metabolite Apoptosis DNA/RNA Synthesis

4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology .

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2

Balixafortide

2 Cited Publications

Cat. No.: HY-P1682

CAS No.: 1051366-32-5

Synonyms: POL6326

Target:

CXCR Arrestin

Research Areas:

Cancer

Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

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2

ZYF0033

2 Cited Publications

Cat. No.: HY-144088

CAS No.: 2380300-79-6

Purity: 98.86%

Synonyms: HPK1-IN-22

Target:

MAP4K

Research Areas:

Inflammation/Immunology Cancer

ZYF0033 is an orally active inhibitor of the hematopoietic progenitor cell kinase HPK1 with an IC50 of less than 10 nM based on the phosphorylation inhibition of MBP protein. ZYF0033 promotes anti-cancer immune responses and reduces phosphorylation of SLP76 (serine 376). ZYF0033 inhibits tumor growth in the 4T-1 syngeneic mouse model and leads to increased intratumoral infiltration of DCs, NK cells, and CD107a ⁺CD8 ⁺ T cells, but not T cells, PD-1 ⁺CD8 ⁺ T cells, TIM-3 ⁺CD8 ⁺ Infiltration of T cells and LAG3 ⁺CD8 ⁺ T cells was reduced .

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2

Balixafortide TFA

2 Cited Publications

Cat. No.: HY-P1682A

Synonyms: POL6326 TFA

Target:

CXCR Arrestin

Research Areas:

Cancer

Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

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1

SB297006

1 Cited Publications

Cat. No.: HY-103361

CAS No.: 58816-69-6

Purity: 99.86%

Target:

CCR

Research Areas:

Neurological Disease Endocrinology

SB297006 is a CCR3 antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells.

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1

Neuropathiazol

1 Cited Publications

Cat. No.: HY-10591

CAS No.: 880090-88-0

Purity: 98.73%

Target:

TGF-β Receptor

Research Areas:

Neurological Disease

Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells .

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1

GSK-3 inhibitor 1

1 Cited Publications

Cat. No.: HY-13973A

CAS No.: 603272-51-1

Purity: 99.16%

Target:

GSK-3

Research Areas:

Metabolic Disease

GSK-3 inhibitor 1 (compound core 3) is a GSK-3 inhibitor that induces stem/progenitor cell self-renewal (e.g. induces stem/progenitor cell proliferation while maintaining the ability to differentiate into tissue cells in the progeny) .

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