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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
prokineticin
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "prokineticin" in MCE Product Catalog:
Synonyms: PKRA7
Target:
Research Areas:
PKRA83 (PKRA7) is a potent prokineticin (PK2) antagonist, which can compete for the binding of PK2 to its receptors PKR1 and PKR2. PKRA83 potently inhibits PK2 receptors, with IC50 values of 5.0 nM and 8.2 nM for PKR1 and PKR2, respectively. PKRA83 has anticancer, anti-arthritis and anti-angiogenic activities. .
Cat. No.: HY-P4815
CAS No.: 423206-00-2
Target:
Research Areas:
Cat. No.: HY-125807
CAS No.: 324561-95-7
Target:
G Protein-coupled Receptor Kinase (GRK) Apoptosis Reactive Oxygen Species (ROS) Akt p38 MAPK
Research Areas:
IS20 is a Prokineticin receptor 1 (PKR1) agonist. IS20 diminishes Doxorubicin (HY-15142A) mediated apoptosis and ROS production by activating Akt or MAPK pathways. IS20 protects the heart against Doxorubicin-induced cardiovascular toxicity and improves the survival rate and cardiac function in mouse models. IS20 does not alter the cytotoxicity and antitumor activity of acute DOX treatment in breast cancer cells and MDA-MB-231 xenograft mouse models. IS20 can be used for cancers research .
Cat. No.: HY-129317
CAS No.: 1233923-95-9
Target:
Research Areas:
A457 is a prokineticin receptor PKR2 antagonist, with an IC50 of 102 nM. A457 can rescue the cell surface expression and function of P290S PKR2, but not W178S and G234D PKR2 .
Cat. No.: HY-P71906
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PROK1; PK1; prokineticin 1; Endocrine-Gland-Derived Vascular Endothelial Growth Factor; EG-VEGF; Black Mamba Toxin-Related Protein; Mambakine; prokineticin-1; EGVEGF; Endocrine Gland-Derived Vascular Endothelial Growth Factor; PRK1
Species:
Human
Source:
E. coli
Cat. No.: HY-P704533
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PROK2; MIT1; prokineticin 2; KAL4; PK2; prokineticin-2; BV8; HH4; Protein Bv8 Homolog
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P74616
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PROK1; PK1; prokineticin 1; Endocrine-Gland-Derived Vascular Endothelial Growth Factor; EG-VEGF; Black Mamba Toxin-Related Protein; Mambakine; prokineticin-1; EGVEGF; Endocrine Gland-Derived Vascular Endothelial Growth Factor; PRK1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P78016
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PROK1; PK1; prokineticin 1; Endocrine-Gland-Derived Vascular Endothelial Growth Factor; EG-VEGF; Black Mamba Toxin-Related Protein; Mambakine; prokineticin-1; EGVEGF; Endocrine Gland-Derived Vascular Endothelial Growth Factor; PRK1
Species:
Mouse
Source:
HEK293
Cat. No.: HY-153201
CAS No.: 910113-34-7
Research Areas:
PKR1 antagonist-2 is a non-peptide prokineticin receptor antagonist that preferentially binds to and blocks PK-R1 signaling while also blocking PK-R2. PKR1 antagonist-2 shifts the autoimmune response against myelin from a Th1/Th17 profile toward a Th2 profile, reducing myelin antigen-specific T cell proliferation and the production of proinflammatory cytokines (IFN-γ, TNF, IL-6, IL-17), and increasing the levels of anti-inflammatory cytokines IL-4/IL-10. PKR1 antagonist-2 significantly alleviates disease severity in relapsing-remitting and chronic experimental autoimmune encephalomyelitis (EAE). PKR1 antagonist-2 can be used in research related to multiple sclerosis .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
