881

Z-VAD-FMK

881 Publications Verification

Cat. No.: HY-16658B

CAS No.: 161401-82-7

Synonyms: Z-VAD(OH)-FMK

Target:

Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)

Research Areas:

Inflammation/Immunology Cancer

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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70

Leupeptin hemisulfate

70 Cited Publications

Cat. No.: HY-18234A

CAS No.: 103476-89-7

Category:

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology

Target:

Ser/Thr Protease Cathepsin Autophagy SARS-CoV Atg8/LC3 NO Synthase COX p62 Arginase PTEN NF-κB PI3K Akt p38 MAPK ERK Reactive Oxygen Species (ROS)

Leupeptin hemisulfate is a broad-spectrum protease inhibitor . By inhibiting the activation of the PTEN/PI3K/Akt/NF-κB/ERK1/2/p38 signaling pathway, Leupeptin hemisulfate significantly reduces LPS-induced NO and ROS production, mitochondrial membrane potential hyperpolarization, phagocytic activity, pro-inflammatory cytokine release, and M1 polarization in mouse peritoneal macrophages, and reverses autophagic flux impairment. It also decreases Concanavalin A (HY-P2149)-induced proliferation index of mouse splenic lymphocytes and the Th1/IL-10 and Th2/IL-10 cytokine ratios, thereby modulating innate and adaptive immune responses. Leupeptin hemisulfate inhibits blood coagulation and tumorigenesis in mouse skin. Leupeptin hemisulfate can be used in research on chronic inflammatory diseases and skin tumorigenesis .

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51

DNase I RNase & Protease free

51 Cited Publications

Cat. No.: HY-108882B

CAS No.: 9003-98-9

Target:

DNA/RNA Synthesis

Research Areas:

Inflammation/Immunology

DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune responses. Decreased DNase I activity may be associated with the onset and progression of systemic lupus erythematosus (SLE). DNase I (RNase & Protease free) is a molecular biology-grade DNase I purified by chromatography to remove RNase and protease .

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49

Camostat mesylate

49 Cited Publications

Cat. No.: HY-13512

CAS No.: 59721-29-8

Purity: 99.94%

Synonyms: Camostat mesilate; FOY305; FOY-S980

Target:

Ser/Thr Protease SARS-CoV

Research Areas:

Infection Inflammation/Immunology

Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

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46

Asunaprevir

46 Cited Publications

Cat. No.: HY-14434

CAS No.: 630420-16-5

Purity: 99.84%

Synonyms: BMS-650032

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Asunaprevir (BMS-650032) is a potent and orally bioavailable hepatitis C virus (HCV) NS3 protease inhibitor, with IC₅₀ of 0.2 nM-3.5 nM . Asunaprevir inhibits SARS-CoV-2 3CL ^pro activity .

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44

Telaprevir

44 Cited Publications

Cat. No.: HY-10235

CAS No.: 402957-28-2

Purity: 99.54%

Synonyms: VX-950

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (K_i) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide . Telaprevir inhibits SARS-CoV-2 3CL ^pro activity .

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36

Pyridostatin trihydrochloride

36 Cited Publications

Cat. No.: HY-15176C

CAS No.: 2517456-88-9

Synonyms: RR82 trihydrochloride

Target:

DNA/RNA Synthesis G-quadruplex Flavivirus Src Virus Protease

Research Areas:

Cancer

Pyridostatin (RR82) trihydrochloride is a G-quadruplex (G4) inducer/stabilizer with a K_d of 490 nM. Pyridostatin trihydrochloride also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC₅₀ of 11.0 μM. Pyridostatin trihydrochloride interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin trihydrochloride exhibits antiproliferative and antiviral activities. Pyridostatin trihydrochloride can be used in studies related to breast cancer, cervical cancer, and Zika virus infection .

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36

Pyridostatin TFA

36 Cited Publications

Cat. No.: HY-15176B

CAS No.: 1472611-44-1

Purity: 99.54%

Synonyms: RR82 TFA

Target:

DNA/RNA Synthesis G-quadruplex Flavivirus Src Virus Protease

Research Areas:

Cancer

Pyridostatin (RR82) TFA is a G-quadruplex (G4) inducer/stabilizer with a K_d of 490 nM. Pyridostatin TFA also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC₅₀ of 11.0 μM. Pyridostatin TFA interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin TFA exhibits antiproliferative and antiviral activities. Pyridostatin TFA can be used in studies related to breast cancer, cervical cancer, and Zika virus infection .

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34

Boceprevir

34 Cited Publications

Cat. No.: HY-10237

CAS No.: 394730-60-0

Purity: 98.52%

Synonyms: EBP 520; SCH 503034

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a K_i of 14 nM in both enzyme assay and an EC₉₀ of 350 nM in cell-based replicon assay . Boceprevir inhibits SARS-CoV-2 3CL ^pro activity .

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30

Grazoprevir

30 Cited Publications

Cat. No.: HY-15298

CAS No.: 1350514-68-9

Purity: 99.99%

Synonyms: MK-5172

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir inhibits SARS-CoV-2 3CL ^pro activity .

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30

Grazoprevir potassium salt

30 Cited Publications

Cat. No.: HY-15298A

CAS No.: 1206524-86-8

Purity: 99.63%

Synonyms: MK-5172 potassium salt

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir potassium salt inhibits SARS-CoV-2 3CL ^pro activity .

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30

Grazoprevir hydrate

30 Cited Publications

Cat. No.: HY-15298B

CAS No.: 1350462-55-3

Purity: 99.99%

Synonyms: MK-5172 hydrate

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir hydrate inhibits SARS-CoV-2 3CL ^pro activity .

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20

Saquinavir mesylate

20 Cited Publications

Cat. No.: HY-17003

CAS No.: 149845-06-7

Synonyms: Ro 31-8959/003

Target:

HIV HIV Protease Apoptosis Reactive Oxygen Species (ROS) Calcium Channel NO Synthase Interleukin Related Toll-like Receptor (TLR) p38 MAPK JNK

Research Areas:

Infection Cardiovascular Disease Inflammation/Immunology

Saquinavir (Ro 31-8959) mesylate is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir mesylate also has anti-inflammatory activity and can induce apoptosis of human red blood cells .

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20

Saquinavir

20 Cited Publications

Cat. No.: HY-17007

CAS No.: 127779-20-8

Synonyms: Ro 31-8959

Target:

HIV HIV Protease Apoptosis Reactive Oxygen Species (ROS) Calcium Channel NO Synthase Interleukin Related Toll-like Receptor (TLR) p38 MAPK JNK

Research Areas:

Infection Cardiovascular Disease Inflammation/Immunology

Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells .

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19

Darunavir

19 Cited Publications

Cat. No.: HY-17040

CAS No.: 206361-99-1

Synonyms: TMC114; UIC-94017

Target:

HIV HIV Protease

Research Areas:

Infection Inflammation/Immunology

Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC₅₀ = 0.003 μM; IC₉₀ = 0.009 μM) with minimal cytotoxicity .

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16

6-Thioguanine

16 Cited Publications

Cat. No.: HY-13765

CAS No.: 154-42-7

Purity: 99.90%

Synonyms: Thioguanine; 2-Amino-6-purinethiol

Category:

Infection Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:

SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite

6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

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12

Tipranavir

12 Cited Publications

Cat. No.: HY-15148

CAS No.: 174484-41-4

Purity: ≥98.0%

Synonyms: PNU-140690

Target:

HIV Protease HIV SARS-CoV

Research Areas:

Infection

Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL ^pro activity .

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