814 Results for "

proteasomes

" in MedChemExpress (MCE) Product Catalog:

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2335

MG-132

2335 Publications Verification

Cat. No.: HY-13259

CAS No.: 133407-82-6

Purity: 99.90%

Synonyms: Z-Leu-Leu-Leu-al; MG132

Target:

Proteasome Autophagy Apoptosis

Research Areas:

Cancer

MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

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286

Bortezomib

286 Cited Publications

Cat. No.: HY-10227

CAS No.: 179324-69-7

Purity: 99.91%

Synonyms: PS-341; LDP-341; NSC 681239

Target:

Proteasome NF-κB Apoptosis Autophagy TREM receptor Ligands for Target Protein for PROTAC

Research Areas:

Cancer

Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

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