20

Dexrazoxane hydrochloride

20 Publications Verification

Cat. No.: HY-76201

CAS No.: 149003-01-0

Synonyms: ICRF-187 hydrochloride; ADR-529 hydrochloride; NSC-169780 hydrochloride

Target:

Apoptosis Ferroptosis

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer

Dexrazoxane hydrochloride (ICRF-187 hydrochloride) is a heart protectant that can help preserve ovarian function and fertility. Dexrazoxane hydrochloride has antioxidant and anti-inflammatory properties, can cross the blood-brain barrier, improves motor function disorders, and offers neuroprotective effects, making it useful in the study of neurodegenerative diseases .

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11

D-(+)-Trehalose

11 Cited Publications

Cat. No.: HY-N1132

CAS No.: 99-20-7

Synonyms: D-Trehalose; α,α-Trehalose

Category:

Polysaccharides Other Diseases Endogenous metabolite Disease Research Fields Saccharides

Target:

Endogenous Metabolite

D-(+)-Trehalose (α,α-Trehalose) is an orally active disaccharide, showing anti-desiccant and cryopreservative activities. D-(+)-Trehalose acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. D-(+)-Trehalose can be used as a food ingredient and pharmaceutical excipient .

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11

Idebenone

11 Cited Publications

Cat. No.: HY-N0303

CAS No.: 58186-27-9

Target:

Mitochondrial Metabolism Apoptosis

Research Areas:

Neurological Disease

Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC₅₀=16.65 μM) . Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells . Idebenone quickly crosses the blood-brain barrier.

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7

Oxybenzone

7 Cited Publications

Cat. No.: HY-A0067

CAS No.: 131-57-7

Synonyms: Benzophenone 3

Target:

Environmental Pollutants Autophagy RAR/RXR Apoptosis

Research Areas:

Neurological Disease

Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

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5

Carboxin

5 Cited Publications

Cat. No.: HY-B2064

CAS No.: 5234-68-4

Synonyms: Carboxine; Fenoxan

Category:

Infection Natural Products Microorganisms Disease Research Fields

Target:

Environmental Pollutants Antibiotic Fungal

Carboxin (Carboxine) is a systemic agricultural fungicide and seed protectant.

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1

Manninotriose

1 Cited Publications

Cat. No.: HY-N0913

CAS No.: 13382-86-0

Category:

Polysaccharides Other Diseases Plants Other Families Extract Disease Research Fields Saccharides

Target:

Thymidylate Synthase Antifolate

Manninotriose is a natural functional trisaccharide composed of three mannose molecules. Manninotriose binds to dihydrofolate reductase via hydrogen bond formation with Arg28. Manninotriose binds to thymidylate synthase via hydrogen bond formation with Arg50. Manninotriose acts as a membrane protectant and helps improve stress tolerance. Manninotriose can be used in research related to acute lymphoblastic leukemia .

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Ectoine

Cat. No.: HY-107784

CAS No.: 96702-03-3

Purity: 99.34%

Category:

Microorganisms Amino acids Disease Research Fields Inflammation/Immunology

Target:

Bacterial

Ectoine is a natural cell protectant, an amino acid derivate produced by bacteria living under extremely harsh environmental conditions. Ectoine serves as an osmoregulatory compatible solute, increasing the hydration of the skin surface and stabilizing lipid layers, which is useful in skincare. Ectoine demonstrates a good safety profile for the treatment of allergic rhinitis .

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Dextran T1 (MW 1,000)

Cat. No.: HY-112624A

CAS No.: 9004-54-0

Synonyms: Dextran 1; Dextran D1; Dextran T1(MW 800-1200)

Dextran T1 (Dextran 1; Dextran D1) (with a molecular weight of 1,000) is a dehydrated glucose polymer with an average molecular weight of 1,000. Dextran T1 (MW 1,000) has excellent biodegradability and biocompatibility, and can be used as a nanobody carrier scaffold and a freeze-drying protectant. Dextran T1 (MW 1,000) promotes the retention of circulating tumor cells in the capillary bed .

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EPI-743

Cat. No.: HY-16772

CAS No.: 1213269-98-7

Synonyms: α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075

Target:

Mitochondrial Metabolism Ferroptosis

Research Areas:

Neurological Disease

EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione .

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3-Bromo-5-chloropyridine

Cat. No.: HY-W003165

CAS No.: 73583-39-8

3-Bromo-5-chloropyridine is a widely used heterocyclic compound that can be used to synthesize compounds. 3-Bromo-5-chloropyridine can be used as an intermediate in the production of crop protectants in the agricultural chemicals industry. 3-Bromo-5-chloropyridine can participate in cross-coupling reactions .

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Sodium lactate ringer's solution

Cat. No.: HY-158976

Synonyms: Lactated ringer's solution (LRS)

Target:

Biochemical Assay Reagents Collagen HSP

Research Areas:

Inflammation/Immunology

Sodium lactate ringer's solution (Lactated ringer's solution (LRS)) is an isotonic crystal intravenous injection and arthroscopic irrigation solution containing racemic sodium lactate and electrolytes such as sodium, potassium, calcium and chloride (130 mEq sodium/L, 274 mOsm/L), which can be used as a cell integrity protectant. Sodium lactate ringer's solution maintains the integrity of human meniscus cells, ensures that they retain normal cell morphology, membrane regularity, size and density, and does not alter the mRNA expression levels of α1 (I) procollagen, α1 (II) procollagen, aggrecan or HSP70. Sodium lactate ringer's solution can be applied to studies related to extracellular fluid deficiency and meniscus tears .

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