1087 Results for "

protein interaction

" in MedChemExpress (MCE) Product Catalog:

Products (1087)

Sort by :

Categories

By Targets

Species:

Tags:

Sources:

Hosts:

Reactivities:

Applications:

Isotypes:

Conjugations:

Clonalities:

Modifications:

Products

266

Angiotensin II human

266 Publications Verification

Cat. No.: HY-13948

CAS No.: 4474-91-3

Purity: 99.98%

Synonyms: Angiotensin II; Ang II; DRVYIHPF

Category:

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Angiotensin Receptor Apoptosis

Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

266

Angiotensin II human acetate

266 Publications Verification

Cat. No.: HY-13948A

CAS No.: 68521-88-0

Purity: 99.62%

Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate

Target:

Angiotensin Receptor Apoptosis

Research Areas:

Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer

Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

266

Angiotensin II human TFA

266 Publications Verification

Cat. No.: HY-13948B

CAS No.: 2761969-44-0

Purity: 98.84%

Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA

Target:

Angiotensin Receptor Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

232

Streptavidin Magnetic Beads

232 Cited Publications

Cat. No.: HY-K0208

MCE Streptavidin Magnetic Beads provide a fast and convenient method for numerous applications, including purification of proteins and nucleic acids, protein interaction studies, immunoprecipitation, immunoassays, pull-down and cell isolation. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Please select quantity

August 31

Get Quote

View All Sizes

202

Doxycycline monohydrate

202 Cited Publications

Cat. No.: HY-W008923

CAS No.: 17086-28-1

Target:

MMP Parasite Bacterial Antibiotic Apoptosis Akt PI3K

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Doxycycline monohydrate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline monohydrate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline monohydrate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline monohydrate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline monohydrate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline monohydrate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

Nutlin-3a

81 Cited Publications

Cat. No.: HY-10029

CAS No.: 675576-98-4

Purity: 99.00%

Synonyms: Rebemadlin

Target:

MDM-2/p53 E1/E2/E3 Enzyme Autophagy Apoptosis

Research Areas:

Cancer

Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC₅₀=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

ICG-001

69 Cited Publications

Cat. No.: HY-14428

CAS No.: 780757-88-2

Purity: 99.86%

Target:

β-catenin Apoptosis

Research Areas:

Cancer

ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. ICG-001 works by specifically binding to cyclic AMP response element-binding protein with an IC₅₀ of 3 μM. ICG-001 selectively blocks the β-catenin/CBP interaction without interfering with the β-catenin/p300 interaction.

Compare

Please select quantity

August 31

Get Quote

View All Sizes

AP20187

55 Cited Publications

Cat. No.: HY-13992

CAS No.: 195514-80-8

Purity: 99.85%

Synonyms: B/B Homodimerizer

Target:

FKBP

Research Areas:

Metabolic Disease

AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.

Compare