34

5Z-7-Oxozeaenol

34 Publications Verification

Cat. No.: HY-12686

CAS No.: 253863-19-3

Purity: 99.30%

Synonyms: FR148083; L783279; LL-Z 1640-2

Category:

Natural Products Microorganisms Monophenols Phenols Disease Research Fields Inflammation/Immunology

Target:

MAP3K VEGFR Antibiotic

5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC₅₀s of 8 nM and 52 nM, respectively.

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3

bpV(phen)

3 Cited Publications

Cat. No.: HY-136065

CAS No.: 42494-73-5

Purity: ≥98.0%

Target:

PTEN Phosphatase Parasite Apoptosis

Research Areas:

Infection Metabolic Disease Inflammation/Immunology Cancer

bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

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3

BpV(phen) trihydrate

3 Cited Publications

Cat. No.: HY-122818

CAS No.: 171202-16-7

Purity: ≥98.0%

Synonyms: Bisperoxovanadium(phen) trihydrate

Target:

PTEN Phosphatase Parasite Apoptosis

Research Areas:

Infection Metabolic Disease Inflammation/Immunology Cancer

BpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. BpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). BpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

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1

CK-2-68

1 Cited Publications

Cat. No.: HY-117897

CAS No.: 1361004-87-6

Purity: 98.91%

Target:

Parasite

Research Areas:

Infection

CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC₅₀ of 40 nM .

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Quinfamide

Cat. No.: HY-119826

CAS No.: 62265-68-3

Purity: 99.69%

Synonyms: WIN-40014

Target:

Parasite

Research Areas:

Infection

Quinfamide (WIN-40014) is an orally active class of dichloroacetyl derivative with significant anti-intestinal protozoan, particularly mmoeba histolytica activity. Quinfamide exhibits antiamoebic activity under solvent-free conditions with an IC₅₀ of 28.15 μg/mL in a suspension condition. Quinfamide particles are actively engulfed by the amoebas, then cells are affected, and finally, amoebas are killed and lysed, and this process directly relies on the physical intake of the drug particles. Quinfamide can be used in the research of tropical parasitic infections such as amoebiasis and helminthiasis .

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HMMNI

Cat. No.: HY-W008216

CAS No.: 936-05-0

Synonyms: Hydroxy Dimetridazole

Target:

Drug Metabolite Parasite

Research Areas:

Infection

HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole (HY-B1244). Dimetridazole is a nitroimidazole class drug that combats protozoan infections .

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2′-Deoxy-GDP trisodium

Cat. No.: HY-W013111

CAS No.: 102783-74-4

Synonyms: dGDP trisodium; 2'-Deoxyguanosine-5'-diphosphate trisodium

Target:

Nucleoside Antimetabolite/Analog Parasite

Research Areas:

Infection

2′-Deoxy-GDP (dGDP) trisodium, a guanosine monophosphate (GMP) analogue, is a hypoxanthine phosphoribosyltransferase (HGPRT) inhibitor with an IC₅₀ of 12.5 μM. HGPRT is a central enzyme in the purine recycling pathway of all protozoan parasites .

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Prolylvaline

Cat. No.: HY-135158

CAS No.: 20488-27-1

Purity: 99.53%

Synonyms: Val-Pro; H-Val-Pro-OH

Target:

Inhibitory Antibodies

Research Areas:

Others

Prolylvaline (Pro-Val) is a proline-valine dipeptide that can be used to bind fluorescein isothiocyanate (FITC). Prolylvaline has specific imprinting effects in Tetrahymena, inducing negative imprinting. Using protozoan organisms, proline dipeptides containing different partner amino acids can be distinguished from dipeptides with opposite amino acid positions .

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HMMNI-d3

Cat. No.: HY-W008216S

CAS No.: 1015855-78-3

Synonyms: Hydroxy Dimetridazole-d₃

HMMNI-d₃ (Hydroxy Dimetridazole-d₃) is deuterium labeled HMMNI (HY-W008216). HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazol (HY-B1244). Dimetridazole is a nitroimidazole class agent that combats protozoan infections .

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Questin

Cat. No.: HY-137990

CAS No.: 3774-64-9

Purity: 97.75%

Category:

Marine natural products Endogenous metabolite Infection Quinones Human Gut Microbiota Metabolites Microorganisms Anthraquinones Phenols Polyphenols Disease Research Fields Marine microorganism

Target:

Bacterial Parasite Phosphatase

Questin is an anthraquinone compound and antibacterial agent. Questin can be isolated from marine-derived fungi and plants. Questin inhibits Cdc25B phosphatase. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL. Questin displays antiprotozoal activity against the animal protozoan pathogen Tritrichomonas foetus, with a MIC of 12.5 µg/mL. Questin has anticancer activity against lung and colon cancer .

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Megazol

Cat. No.: HY-119480

CAS No.: 19622-55-0

Purity: 99.20%

Target:

Bacterial

Research Areas:

Infection

Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC₅₀ of 0.01 μg/mL. Megazol can be used for the research of protozoan infections .

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Teclozan

Cat. No.: HY-19594

CAS No.: 5560-78-1

Synonyms: WIN 13146

Target:

Parasite

Research Areas:

Infection

Teclozan (WIN 13146) is an antiprotozoal agent, class in benzylamine derivatives. Teclozan intervenes in the phospholipid metabolism preventes the formation of arachidonic acid. Teclozan acts in the intestinal lumen being effective in Anti-G. intestinalis. Teclozan can be used for the research of protozoan infections .

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N-(2-Hydroxyethyl)oxamic acid

Cat. No.: HY-138094

CAS No.: 5270-73-5

Target:

Drug Metabolite

Research Areas:

Infection

N-(2-hydroxyethyl)-oxamic acid is formed when Metronidazole is reduced either chemically or by the action of the intestinal bacteria. Metronidazole, a nitroimidazole antibiotic, has activity against various protozoans and most Gram-negative and Gram-positive anaerobic bacteria .

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