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34 Results for "

pulmonary damage

" in MedChemExpress (MCE) Product Catalog:

Products (34)

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KI696

23 Publications Verification

Cat. No.: HY-101140

CAS No.: 1799974-70-1

Purity: 98.67%

Target:

Keap1-Nrf2 Quinone Reductase

Research Areas:

Inflammation/Immunology

KI696 is a selective KEAP1/NRF2 protein-protein interaction inhibitor with a human K_d value of 1.3 nM. KI696 acts by competitively occupying the NRF2-binding pocket of the KEAP1 Kelch domain. KI696 blocks KEAP1-mediated ubiquitination and degradation of NRF2, promotes the translocation of NRF2 to the nucleus, activates the expression of downstream antioxidant genes, increases intracellular glutathione levels, and alleviates oxidative stress-induced cell damage and inflammatory cell infiltration in the lungs. KI696 reduces ozone-induced pulmonary oxidative damage and inflammatory cell accumulation in rats, and upregulates pulmonary antioxidant genes. KI696 can be used in research related to chronic obstructive pulmonary disease, oxidative stress and inflammation .

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Indacaterol

5 Cited Publications

Cat. No.: HY-14299

CAS No.: 312753-06-3

Purity: 99.98%

Target:

Adrenergic Receptor

Research Areas:

Cardiovascular Disease Endocrinology Cancer

Indacaterol is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol can also be used in cardiovascular disease research .

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Indacaterol maleate

5 Cited Publications

Cat. No.: HY-14299A

CAS No.: 753498-25-8

Purity: 99.82%

Synonyms: QAB149

Target:

Adrenergic Receptor

Research Areas:

Cardiovascular Disease Endocrinology Cancer

Indacaterol maleate (QAB149) is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol maleate inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol maleate can also be used in cardiovascular disease research .

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Itepekimab

1 Cited Publications

Cat. No.: HY-P99673

CAS No.: 2226742-52-3

Synonyms: REGN3500; SAR-440340

Target:

Interleukin Related NF-κB

Research Areas:

Inflammation/Immunology

Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against IL-33. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD) .

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