Synonyms: 2-pyridone

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

α-Pyridone (2-Pyridone) is an antibacterial agent that plays an important role in the field of biochemical research. α-Pyridone can serve as a scaffold compound to synthesize a variety of active compounds .

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12

Pyridone 6

12 Cited Publications

Cat. No.: HY-14435

CAS No.: 457081-03-7

Purity: 98.20%

Target:

JAK

Research Areas:

Cancer

Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC₅₀s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.

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1

3,5,6-Trichloro-2-pyridinol

1 Cited Publications

Cat. No.: HY-W018171

CAS No.: 6515-38-4

Synonyms: TCPy

Target:

Environmental Pollutants Herbicide

Research Areas:

Metabolic Disease Inflammation/Immunology

3,5,6-Trichloro-2-pyridinol (TCPy) is a chloride of 2-pyridone with oral activity. 3,5,6-Trichloro-2-pyridinol is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and chlorpyrifos-methyl. 3,5,6-Trichloro-2-pyridinol is associated with attention deficit hyperactivity disorder (ADHD) and decreased testosterone levels. 3,5,6-Trichloro-2-pyridinol causes hearing loss, hepatotoxicity and nephrotoxicity in mice .

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N-Methyl-4-pyridone-3-carboxamide

Cat. No.: HY-113472

CAS No.: 769-49-3

Purity: 99.6%

Target:

Drug Metabolite

Research Areas:

Others

N-Methyl-4-pyridone-3-carboxamide (compound 4PY) is a final product of nicotinamide adenine dinucleotide (NAD) degradation .

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GDC-3280

Cat. No.: HY-160851

CAS No.: 1590403-33-0

Synonyms: AK3287; AKEX0011

Target:

ASK1 p38 MAPK

Research Areas:

Inflammation/Immunology

GDC-3280 (AK3287; AKEX0011) is an orally active compound based on Pirfenidone (HY-B0673)'s phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects .

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NITD-916

Cat. No.: HY-122643

CAS No.: 1614262-83-7

Purity: 99.83%

Target:

Bacterial

Research Areas:

Infection

NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active mycobacterial enoyl reductase InhA inhibitor with an IC₅₀ of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 inhibition of InhA reduces the synthesis of mycolic acids and results in cell death. NITD-916 has potent anti-tuberculosis effects .

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