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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
85 Results for "
pyrrolidine
" in MedChemExpress (MCE) Product Catalog:
Products (85)
85 Results for "pyrrolidine" in MCE Product Catalog:
1
1 Cited Publications
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ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM .
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1 Cited Publications
Cat. No.: HY-145001
Purity: 99.69%
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20-HC-Me-Pyrrolidine (compound AI-3d) is a potent Aster protein inhibitor with IC50s of 0.11 μM, 0.06 μM, and 0.71 μM for Aster-A, Aster-B, and Aster-C, respectively. 20-HC-Me-Pyrrolidine blocks the ability of Asters to bind and transfer cholesterol. 20-HC-Me-Pyrrolidine also inhibits the movement of low-density lipoprotein (LDL) cholesterol to the endoplasmic reticulum (ER) .
Synonyms: (+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline
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Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
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Cat. No.: HY-W002421
CAS No.: 122536-77-0
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1-Methylpyrrolidine is a methylated pyrrolidine, and cation with thermal-origin negative nonlinear optical (self-defocusing) properties .
Cat. No.: HY-79691
CAS No.: 122536-76-9
Cat. No.: HY-W008129
CAS No.: 2584-71-6
Category:
Ketones, Aldehydes, Acids Metabolic Disease Amino acids Microorganism Disease Research Fields
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Cat. No.: HY-W012071
CAS No.: 16652-71-4
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(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride is an intermediate in the synthesis of L-proline derivative peptides. (S)-Benzyl pyrrolidine-2-carboxylate hydrochloride is a key raw material for the synthesis of apoptosis inhibitor protein (IAP) antagonists and SMAC mimic tripeptide fragments (Boc-MeAla-Tle-Pro-OH). (S)-Benzyl pyrrolidine-2-carboxylate hydrochloride can be used to synthesize divalent quinazoline IAP antagonists .
Cat. No.: HY-W001294
CAS No.: 109431-87-0
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(R)-(-)-N-Boc-3-pyrrolidinol is a chiral pyrrolidine derivative. After undergoing configuration inversion via the Mitsunobu reaction, (R)-(-)-N-Boc-3-pyrrolidinol can serve as a precursor for the (3S)-aryloxypyrrolidine fragment, which is used to construct key intermediates of FXa inhibitors (such as DX-9065a (HY-10722)) and various chiral drugs. (R)-(-)-N-Boc-3-pyrrolidinol can be applied in studies related to arrhythmia .
Cat. No.: HY-W248665A
CAS No.: 2616553-35-4
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Thalidomide-pyrrolidine hydrochloride (Compound 18) is an E3 ligase ligand. Thalidomide-pyrrolidine serves as a building block for the synthesis of PROTAC ARD-1676 (HY-156111) .
Cat. No.: HY-W012921
CAS No.: 62937-45-5
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Cat. No.: HY-W008446
CAS No.: 176486-63-8
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Cat. No.: HY-W007880
CAS No.: 22348-32-9
Synonyms: (R)-Diphenylprolinol
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(R)-D2PM ((R)-Diphenylprolinol) is an isomer of the psychoactive substance D2PM and a pyrrolidine analog .
Cat. No.: HY-400708
CAS No.: 2414393-47-6
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(R)-Benzyl 2-cyclopropyl-2-hydroxyacetate can be used in the synthesis of pyrrolidines, a relevant molecule for ADC applications .
Cat. No.: HY-W151297
CAS No.: 193693-66-2
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(3S)-Fmoc-1-pyrrolidine-3-carboxylic acid is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-60256
CAS No.: 72580-54-2
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Cat. No.: HY-40102
CAS No.: 119020-01-8
Cat. No.: HY-W016638
CAS No.: 479500-35-1
Synonyms: 1-Butyl-1-methylpyrrolidin-1-ium chloride
Cat. No.: HY-W1115222
CAS No.: 2952806-82-3
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(S)-Deoxy-thalidomide-(R)-pyrrolidine-3-carbaldehyde is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
