54

54 Publications Verification

CAS No.: 20111-18-6

Synonyms: β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium

NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance .

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8

McMMAF

8 Cited Publications

Cat. No.: HY-15578

CAS No.: 863971-19-1

Purity: 99.96%

Synonyms: Maleimidocaproyl monomethylauristatin F

Target:

Drug-Linker Conjugates for ADC Microtubule/Tubulin Apoptosis

Research Areas:

Cancer

McMMAF (Maleimidocaproyl monomethylauristatin F) is a drug-linker conjugate for ADCs, formed by coupling the potent microtubule inhibitor Monomethyl auristatin F (MMAF) (HY-15579) with a maleimidocaproyl (mc) linker. McMMAF can be conjugated with anti-BCMA antibodies to form J6M0-mcMMAF, promoting apoptosis and inhibiting tumor growth .

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8

NF449 octasodium

8 Cited Publications

Cat. No.: HY-112461A

CAS No.: 627034-85-9

Purity: 97.39%

Target:

P2X Receptor

Research Areas:

Cardiovascular Disease

NF449 octasodium is a highly potent P2X₁ receptor antagonist, with IC₅₀s of 0.28, 0.69, and 120 nM for rP2X₁, rP2X₁₊₅, P2X₂₊₃, respectively. NF449 octasodium is a G_sα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to G_sα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to G_s .

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7

2-PMPA

7 Cited Publications

Cat. No.: HY-100788

CAS No.: 173039-10-6

Purity: ≥98.0%

Synonyms: 2-(Phosphonomethyl)pentanedioic acid

Target:

Carboxypeptidase

Research Areas:

Neurological Disease

2-PMPA (2-(Phosphonomethyl)pentanedioic acid) is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC₅₀ of 0.0003 μM. 2-PMPA shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA is applicable to the research of neurological diseases .

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7

2-PMPA sodium

7 Cited Publications

Cat. No.: HY-100788C

CAS No.: 373645-42-2

Synonyms: 2-(Phosphonomethyl)pentanedioic acid sodium

Target:

Carboxypeptidase

Research Areas:

Neurological Disease

2-PMPA (2-(Phosphonomethyl)pentanedioic acid) sodium is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC₅₀ of 0.0003 μM. 2-PMPA sodium shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA sodium is applicable to the research of neurological diseases .

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7

GLPG0492

7 Cited Publications

Cat. No.: HY-18102

CAS No.: 1215085-92-9

Target:

Androgen Receptor

Research Areas:

Neurological Disease

GLPG0492 is an orally active, non-steroidal selective androgen receptor modulator. GLPG0492 exerts functional transactivation by binding to the ligand-binding domain of the receptor, exhibiting preferential partial agonist activity in muscle and bone tissues with low activity in reproductive tissues. GLPG0492 effectively counteracts muscle atrophy-related pathways, significantly enhances muscle strength, maintains motor ability, reduces fibrosis and improves electrophysiological parameters. GLPG0492 prevents immobilization-induced muscle atrophy and regulates muscle mass homeostasis, serving as a valuable tool compound for studies on Duchenne muscular dystrophy, muscle loss and various types of disuse musculoskeletal atrophy .

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5

SBI-425

5 Cited Publications

Cat. No.: HY-124756

CAS No.: 1451272-71-1

Purity: 98.88%

Target:

Phosphatase

Research Areas:

Cardiovascular Disease

SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC₅₀=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival .

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5

Sinapinic acid

5 Cited Publications

Cat. No.: HY-W009732

CAS No.: 530-59-6

Synonyms: Sinapic acid

Category:

Monophenols Simple Phenylpropanols Metabolic Disease Phenols Phenylpropanoids Plants Other Families Extract Disease Research Fields

Target:

HDAC Angiotensin-converting Enzyme (ACE) Reactive Oxygen Species (ROS) Apoptosis

Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC₅₀ of 2.27 mM , and also inhibits ACE-I activity . Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells . Sinapinic acid shows antioxidant and antidiabetic activities . Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats .

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3

TRV-120027

3 Cited Publications

Cat. No.: HY-P2141

CAS No.: 1234510-46-3

Synonyms: TRV027

Target:

Angiotensin Receptor Arrestin

Research Areas:

Cardiovascular Disease

TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages β-arrestins while blocking G-protein signaling . TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R-β-arrestin-1-TRPC3-PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment .

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3

TRV-120027 TFA

3 Cited Publications

Cat. No.: HY-P2141A

Target:

Angiotensin Receptor Arrestin

Research Areas:

Cardiovascular Disease

TRV120027 TFA, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ?-arrestins while blocking G-protein signaling . TRV120027?TFA induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the?acute decompensated heart failure (ADHF) treatment .

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