Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
rat GLP-1R
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "rat GLP-1R" in MCE Product Catalog:
Cat. No.: HY-164535
CAS No.: 2887445-76-1
Synonyms: AMG 133
Research Areas:
Maridebart cafraglutide (AMG 133) is a long-acting peptide-antibody conjugate that combines GLP-1 receptor agonist with glucose-dependent insulinotropic polypeptide (GIP) receptor antagonism. Maridebart cafraglutide shows antagonist activity against human, cynomolgus monkey and rat GIPR with IC50 values of 46.4 nM, 26.5 nM, 822.3 nM, respectively. Maridebart cafraglutide shows agonist activity against human, cynomolgus monkey, rat and mouse GLP-1R with EC50 values of 24.4 pM, 5.7 pM, 2.4 pM and 123 pM, respectively. Maridebart cafraglutide can be used for the study of obesity and type 2 diabetes .
Cat. No.: HY-P4389
CAS No.: 1037751-81-7
Target:
Research Areas:
(Asp28)-Glucagon (1-29) (human, rat, porcine) is a glucagon analog and a GCGR agonist, with the Asn at position 28 replaced by Asp. (Asp28)-Glucagon (1-29) (human, rat, porcine) activates GCGR-mediated cAMP signaling, with EC50 values of 0.067 nM and 0.09 nM, respectively, and an EC50 of 7.99 nM for GLP-1R. (Asp28)-Glucagon (1-29) (human, rat, porcine) is useful for studies on glucagon receptor signaling, carbohydrate metabolism, and hypoglycemia .
Cat. No.: HY-P11043
Research Areas:
Cat. No.: HY-RS23066
Target:
Research Areas:
Glp1r Rat Pre-designed siRNA Set A contains three designed siRNAs for Glp1r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P705977
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GLP1R; GLP-1-R; Glucagon Like Peptide 1 Receptor; Seven Transmembrane Helix Receptor; Glucagon-Like Peptide 1 Receptor; GLP1 Receptor; GLP-1R; GLP-1; GLP-1 Receptor
Species:
Rat
Source:
HEK293
Cat. No.: HY-188129
CAS No.: 2889348-10-9
Target:
Research Areas:
GLP-1R modulator-2 is a GLP-1R positive allosteric modulator with an EC50 of 106 nM. GLP-1R modulator-2 simultaneously binds to the extracellular pocket of GLP-1R and the peptide ligand GLP-1 (9-36) through a molecular glue-like allosteric effect, and selectively enhances GLP-1 (9-36)-induced G protein-dependent cAMP signaling. When used in combination with GLP-1 (9-36) under high-glucose conditions, GLP-1R modulator-2 enhances glucose-dependent insulin secretion in wild-type rat pancreatic islets. GLP-1R modulator-2 exhibits strong probe dependence and significantly potentiates the activity of GLP-1 (9-36). GLP-1R modulator-2 can be used for research on type 2 diabetes and obesity .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
