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33 Results for "

rat aorta

" in MedChemExpress (MCE) Product Catalog:

Products (33)

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Cyclopiazonic acid

7 Publications Verification

Cat. No.: HY-N6771

CAS No.: 18172-33-3

Category:

Alkaloids Microorganisms Pyrrole Alkaloids Other Diseases Disease Research Fields Indole Alkaloids

Target:

Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV

Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

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E7820

5 Cited Publications

Cat. No.: HY-14571

CAS No.: 289483-69-8

Purity: 99.06%

Synonyms: ER68203-00

Target:

Molecular Glues Integrin

Research Areas:

Infection Metabolic Disease Cancer

E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 ^DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC₅₀ of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) .

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(D-Pro7)-Angiotensin I/II (1-7)

1 Cited Publications

Cat. No.: HY-P1656

CAS No.: 586962-44-9

Target:

Angiotensin Receptor Mas-related G-protein-coupled Receptor (MRGPR)

Research Areas:

Cardiovascular Disease

(D-Pro7)-Angiotensin I/II (1-7) is a potent Mas receptor inhibitor with a K_i of 0.001 μM for rat receptors. (D-Pro7)-Angiotensin I/II (1-7) competitively blocks the binding of Angiotensin-(1-7) to the Mas receptor and attenuates the vasodilatory effect of rat aortas under physiological and hypertensive conditions. (D-Pro7)-Angiotensin I/II (1-7) can be used for studies on the function of the renin-angiotensin system and the pathological mechanisms of hypertension .

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H-8 dihydrochloride

Cat. No.: HY-112465

CAS No.: 113276-94-1

Purity: 99.00%

Target:

PKA PKC PKG

Research Areas:

Neurological Disease Cancer

H-8 dihydrochloride is a selective Cyclic nucleotide-dependent protein kinase inhibitor. H-8 dihydrochloride potently inhibits cGMP- and cAMP-dependent protein phosphorylation. H-8 dihydrochloride enhances the vasodilatory effect induced by 8-bromo-cAMP (HY-12306A). H-8 dihydrochloride fails to attenuate the vasodilatory effects induced by 8-bromo-cGMP (HY-101379A), atrial natriuretic peptide II, or Sodium nitroprusside (HY-B0564) in rat aorta .

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