198 Results for "

rats model

" in MedChemExpress (MCE) Product Catalog:
Products (198)

198 Results for "rats model" in MCE Product Catalog:

7
Giredestrant
Giredestrant
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7 Publications Verification
Cat. No.: HY-109176
CAS No.: 1953133-47-5
Purity:  99.52%
Synonyms: GDC-9545; RG6171
Target:  

Estrogen Receptor/ERR

Research Areas:  

Endocrinology Cancer

Giredestrant (GDC-9545) is an orally active, full, selective Estrogen receptor α (ERα) degrader and antagonist with a DC50 of 0.03 nM. Giredestrant promotes the degradation of ERα protein, including the ESR1 Y537S mutant ERα. Giredestrant reduces uterine wet weight in immature rats and induces a low cuboidal phenotype in their endometrial epithelium. Giredestrant induces tumor regression in both ESR1 Y537S mutant and wild-type ERα tumor models. Giredestrant can be used for the research of ER + breast cancer .
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6
Asiatic acid
Asiatic acid
0 Images
6 Cited Publications
Cat. No.: HY-N0194
CAS No.: 464-92-6
Category:  

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