27

ONX-0914

27 Publications Verification

Cat. No.: HY-13207

CAS No.: 960374-59-8

Purity: 99.72%

Synonyms: PR-957

Target:

Proteasome Bacterial HIV

Research Areas:

Infection Inflammation/Immunology

ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (K_i=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 .

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27

ONX-0914 TFA

27 Publications Verification

Cat. No.: HY-13207A

Purity: 98.01%

Synonyms: PR-957 TFA

Target:

Proteasome Bacterial HIV

Research Areas:

Infection Inflammation/Immunology

ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (K_i=5.2 μM). ONX-0914 TFA reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 .

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15

RG108

15 Cited Publications

Cat. No.: HY-13642

CAS No.: 48208-26-0

Purity: 99.93%

Synonyms: N-Phthalyl-L-tryptophan

Target:

DNA Methyltransferase

Research Areas:

Inflammation/Immunology Cancer

RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC₅₀=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences .

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7

Procainamide hydrochloride

7 Cited Publications

Cat. No.: HY-A0084

CAS No.: 614-39-1

Synonyms: Procaine amide hydrochloride; SP 100 hydrochloride

Target:

DNA Methyltransferase Potassium Channel

Research Areas:

Cancer

Procainamide hydrochloride (Procaine amide hydrochloride) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide hydrochloride induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide hydrochloride relaxes airway smooth muscle by activating potassium channels. Procainamide hydrochloride can be used in cancer and arrhythmia research .

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7

Procainamide

7 Cited Publications

Cat. No.: HY-A0084A

CAS No.: 51-06-9

Synonyms: Procaine amide; SP 100

Target:

DNA Methyltransferase Potassium Channel

Research Areas:

Cardiovascular Disease Cancer

Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research .

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7

Mizacorat

7 Cited Publications

Cat. No.: HY-120012

CAS No.: 1893415-00-3

Purity: 99.71%

Synonyms: AZD9567

Target:

Glucocorticoid Receptor

Research Areas:

Inflammation/Immunology Endocrinology

Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC₅₀ of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation .

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6

N-Dodecyl-β-D-maltoside

6 Cited Publications

Cat. No.: HY-128974

CAS No.: 69227-93-6

Purity: 99.97%

Synonyms: Lauryl Maltoside

Target:

DNA/RNA Synthesis

Research Areas:

Others

N-Dodecyl-β-D-maltoside (Lauryl Maltoside) is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions .

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6

Divarasib

6 Cited Publications

Cat. No.: HY-145928

CAS No.: 2417987-45-0

Purity: 99.31%

Synonyms: GDC-6036

Target:

Ras

Research Areas:

Cancer

Divarasib (GDC-6036) is an orally active, selective KRAS ^G12C inhibitor with an IC₅₀ of <0.01 μM. Divarasib covalently binds Cys12 in GDP-bound KRAS ^G12C, occupies the switch II pocket, blocks GTP binding and SOS-mediated reactivation, and inhibits oncogenic KRAS signaling. Divarasib induces tumor shrinkage and robust tumor growth inhibition in KRAS ^G12C-positive models and cancer cells. Divarasib can be used for the research of non-small cell lung cancer, colorectal adenocarcinoma, pancreatic ductal adenocarcinoma, and other KRAS ^G12C-mutated solid tumors .

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6

NSC319726

6 Cited Publications

Cat. No.: HY-18634

CAS No.: 71555-25-4

Synonyms: ZMC1

Target:

MDM-2/p53

Research Areas:

Cancer

NSC319726 (ZMC1) is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells.

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6

Divarasib adipate

6 Cited Publications

Cat. No.: HY-145928B

CAS No.: 2762240-36-6

Synonyms: GDC-6036 adipate

Target:

Ras

Research Areas:

Cancer

Divarasib (GDC-6036) adipate is an orally active, selective KRASG12C inhibitor with an IC50 of <0.01 μM. Divarasib adipate covalently binds Cys12 in GDP-bound KRASG12C, occupies the switch II pocket, blocks GTP binding and SOS-mediated reactivation, and inhibits oncogenic KRAS signaling. Divarasib adipate induces tumor shrinkage and robust tumor growth inhibition in KRASG12C-positive models and cancer cells. Divarasib adipate can be used for the research of non-small cell lung cancer, colorectal adenocarcinoma, pancreatic ductal adenocarcinoma, and other KRASG12C-mutated solid tumors .

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