768 Results for "

reactive oxygen

" in MedChemExpress (MCE) Product Catalog:

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935

Erastin

935 Publications Verification

Cat. No.: HY-15763

CAS No.: 571203-78-6

Purity: 99.62%

Target:

VDAC Ferroptosis Disulfidptosis

Research Areas:

Cancer

Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation .

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891

H2DCFDA

891 Cited Publications

Cat. No.: HY-D0940

CAS No.: 4091-99-0

Synonyms: DCFH-DA; 2',7'-Dichlorodihydrofluorescein diacetate

Target:

Fluorescent Dye Reactive Oxygen Species (ROS)

Research Areas:

Others

H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=492/517 nm) .

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881

Z-VAD-FMK

881 Cited Publications

Cat. No.: HY-16658B

CAS No.: 161401-82-7

Synonyms: Z-VAD(OH)-FMK

Target:

Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)

Research Areas:

Inflammation/Immunology Cancer

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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