1851

Ferrostatin-1

1851 Publications Verification

Cat. No.: HY-100579

CAS No.: 347174-05-4

Purity: 99.71%

Synonyms: Fer-1

Target:

Ferroptosis Fungal

Research Areas:

Cancer

Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC₅₀=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity .

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197

Thiazolyl Blue

197 Cited Publications

Cat. No.: HY-15924

CAS No.: 298-93-1

Synonyms: MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide

Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

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72

Exendin-4

72 Cited Publications

Cat. No.: HY-13443

CAS No.: 141758-74-9

Purity: 99.95%

Synonyms: Exenatide

Target:

GLP Receptor Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease

Exendin‑4 (Exenatide) is an orally active, blood-brain barrier-permeable glucagon-like peptide-1 receptor (GLP‑1 receptor) agonist that resists degradation mediated by dipeptidyl peptidase IV. Exendin‑4 mediates multiple glucose-regulating effects, including stimulation of glucose-dependent insulin secretion, inhibition of glucagon production, increase in β-cell mass, delay of gastric emptying, reduction of food intake, improvement of peripheral insulin sensitivity, and restoration of normal islet structure. Exendin‑4 inhibits oxidative stress, alleviates inflammatory responses, and reduces neuronal apoptosis. Exendin‑4 reduces the aggregation level of mutant huntingtin, improves motor function, prolongs survival time, and regulates the expression levels of leptin and ghrelin. Exendin‑4 can be used in research related to type 2 diabetes, acute ischemic stroke, and Huntington's disease .

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72

Exendin-4 acetate

72 Cited Publications

Cat. No.: HY-13443A

CAS No.: 914454-01-6

Purity: 99.91%

Synonyms: Exenatide acetate

Target:

GLP Receptor Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease

Exendin-4 acetate (Exenatide acetate) is an orally active, blood-brain barrier-permeable glucagon-like peptide-1 receptor (GLP‑1 receptor) agonist that resists degradation mediated by dipeptidyl peptidase IV. Exendin-4 acetate mediates multiple glucose-regulating effects, including stimulation of glucose-dependent insulin secretion, inhibition of glucagon production, increase in β-cell mass, delay of gastric emptying, reduction of food intake, improvement of peripheral insulin sensitivity, and restoration of normal islet structure. Exendin-4 acetate inhibits oxidative stress, alleviates inflammatory responses, and reduces neuronal apoptosis. Exendin-4 acetate reduces the aggregation level of mutant huntingtin, improves motor function, prolongs survival time, and regulates the expression levels of leptin and ghrelin. Exendin-4 acetate can be used in research related to type 2 diabetes, acute ischemic stroke, and Huntington's disease .

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40

Paquinimod

40 Cited Publications

Cat. No.: HY-100442

CAS No.: 248282-01-1

Purity: 99.90%

Synonyms: ABR-215757; ABR 25757

Target:

SARS-CoV

Research Areas:

Metabolic Disease Inflammation/Immunology

Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

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37

Milrinone lactate

37 Cited Publications

Cat. No.: HY-14252A

CAS No.: 100286-97-3

Synonyms: Win 47203 lactate

Target:

Phosphodiesterase (PDE)

Research Areas:

Cardiovascular Disease

Milrinone lactate is a potent inotropic dilating agent. Milrinone lactate shows simultaneous positive inotropic and vasodilating activities. Milrinone lactate promotes reduction of SVR and PVR in patients with DCM and NYHA class III and IV of heart failure. Milrinone lactate has the potential for the research of cardiovascular function after cardiac surgery and in septic shock .

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25

TCEP hydrochloride

25 Cited Publications

Cat. No.: HY-W011500

CAS No.: 51805-45-9

Synonyms: Tris(2-carboxyethyl)phosphine hydrochloride

Target:

Drug Derivative

Research Areas:

Others

TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .

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18

Tomivosertib

18 Cited Publications

Cat. No.: HY-100022

CAS No.: 1849590-01-7

Purity: 99.92%

Synonyms: eFT508

Target:

MNK PD-1/PD-L1

Research Areas:

Cancer

Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC₅₀s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC₅₀=2-16 nM) in tumor cell lines . Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance .

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18

Desipramine hydrochloride

18 Cited Publications

Cat. No.: HY-B1272

CAS No.: 58-28-6

Target:

Adrenergic Receptor ERK JNK p38 MAPK NF-κB AP-1 Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism TNF Receptor

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Desipramine hydrochloride is a first-generation tricyclic antidepressant. Desipramine hydrochloride selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine hydrochloride activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine hydrochloride also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine hydrochloride can be used for the research of hepatocellular cancer, inflammation, and neurological diseases .

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17

Gabapentin

17 Cited Publications

Cat. No.: HY-A0057

CAS No.: 60142-96-3

Target:

Calcium Channel

Research Areas:

Neurological Disease Cancer

Gabapentin is a potent, orally active P/Q type Ca ²⁺ channel blocker. Gabapentin inhibits neuronal Ca ²⁺ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain .

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17

Gabapentin hydrochloride

17 Cited Publications

Cat. No.: HY-A0057A

CAS No.: 60142-95-2

Target:

Calcium Channel

Research Areas:

Neurological Disease Cancer

Gabapentin hydrochloride is a potent, orally active P/Q type Ca ²⁺ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca ²⁺ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain .

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16

MK-0752

16 Cited Publications

Cat. No.: HY-10974

CAS No.: 471905-41-6

Purity: 99.35%

Target:

γ-secretase

Research Areas:

Neurological Disease Cancer

MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC₅₀ of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo .

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12

Riboflavin

12 Cited Publications

Cat. No.: HY-B0456

CAS No.: 83-88-5

Synonyms: Vitamin B2; E101

Category:

Human Gut Microbiota Metabolites Natural Products Microorganisms Other Diseases Endogenous metabolite Disease Research Fields

Target:

Environmental Pollutants Endogenous Metabolite Bacterial

Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction .

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12

JBSNF-000088

12 Cited Publications

Cat. No.: HY-112584

CAS No.: 7150-23-4

Purity: 99.94%

Synonyms: 6-Methoxynicotinamide

Target:

Amine N-methyltransferase

Research Areas:

Metabolic Disease

JBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent and orally active Nicotinamide N-methyltransferase (NNMT) inhibitor with IC₅₀s of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease .

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