2 Results for "

retinal bioavailability

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "retinal bioavailability" in MCE Product Catalog:

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Cat. No.: HY-Y0669
CAS No.: 535-75-1
Pipecolic acid is an orally bioavailable, blood-brain barrier-permeable metabolite of lysine with antioxidant, inhibitor, and inducer activity. Pipecolic acid modulates the YAP-GPX4 signaling pathway, reduces retinal vascular tube formation, and mitigates ferroptosis. Pipecolic acid potentiates voltage-sensitive Ca 2+ channel currents and induces neuronal apoptosis. Pipecolic acid can be used for the research of diabetic retinopathy .
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Cat. No.: HY-159962
CAS No.: 2244702-64-3
Target:  

Glutaminase

Research Areas:  

Metabolic Disease

TGase2-IN-1 (Compound 22) is an orally active inhibitor for TGase2 with an IC50 of 1.12 μM. TGase2-IN-1 inhibits TGase2 in human retinal microvascular endothelial cells with an IC50 of 0.07 μM. TGase2-IN-1 exhibits 74.6% oral bioavailability. TGase2-IN-1 inhibits retinal vascular leakage in mouse Streptozotocin (HY-13753)-induced diabetic model .
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