4

Retinyl acetate

4 Cited Publications

Cat. No.: HY-N0679

CAS No.: 127-47-9

Synonyms: retinol acetate; Vitamin A acetate

Category:

Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Cancer

Target:

Environmental Pollutants

Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities .

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4

Win 18446

4 Cited Publications

Cat. No.: HY-W011094

CAS No.: 1477-57-2

Target:

Aldehyde Dehydrogenase (ALDH)

Research Areas:

Endocrinology

Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC₅₀ of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes .

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3

All-trans-retinal

3 Cited Publications

Cat. No.: HY-W004500

CAS No.: 116-31-4

Category:

Human Gut Microbiota Metabolites Microorganisms Terpenoids Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Apoptosis

All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis .

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2

A 1120

2 Cited Publications

Cat. No.: HY-107633

CAS No.: 1152782-19-8

Purity: 99.73%

Target:

Transthyretin (TTR)

Research Areas:

Metabolic Disease

A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a K_i value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin .

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1

Retinyl palmitate

1 Cited Publications

Cat. No.: HY-B1384

CAS No.: 79-81-2

Synonyms: Vitamin A palmitate; retinol palmitate

Category:

Other Diseases Lipids Cosmetic Research Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Retinyl palmitate is an ester of Retinol and is the major form of vitamin A found in the epidermis. Retinyl palmitate has been widely used in researches of pharmaceutical and cosmetic formulations .

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1

4-Hydroxyretinoic acid

1 Cited Publications

Cat. No.: HY-125904

CAS No.: 66592-72-1

Purity: 95.11%

Target:

RAR/RXR UGT Cytochrome P450 Apoptosis Drug Derivative

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

4-Hydroxyretinoic acid (4-HRA) is a derivative of Retinoic acid (HY-14649). 4-Hydroxyretinoic acid is formed via the catalysis of retinol by cytochrome P-450 isoenzymes. 4-Hydroxyretinoic acid also serves as a substrate for UDP-glucuronosyltransferase (s) and recombinant UGT2B7. 4-Hydroxyretinoic acid binds to the nuclear receptor RAR (Retinoic Acid Receptor), activates RAR and RXR-alpha, subsequently regulates gene expression and cell differentiation, and induces cancer cell apoptosis (Apoptosis). 4-Hydroxyretinoic acid also participates in multiple physiological processes such as immunoregulation, neuroprotection and antioxidation .

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1

RBP4 Protein, Human (HEK293, hFc)

1 Cited Publications

Cat. No.: HY-P72031

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: RBP4; retinol-Binding Protein 4, Interstitial; retinol Binding Protein 4; retinol-Binding Protein 4, Plasma; Plasma retinol-Binding Protein; retinol Binding Protein 4, Plasma; retinol-Binding Protein 4; retinol-Binding Protein; PRBP; MCOPCB10; RBP; RDCCAS

Species:

Human

Source:

HEK293

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1

RBP4 Protein, Rat (HEK293, His)

1 Cited Publications

Cat. No.: HY-P74598

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: RBP4; retinol-Binding Protein 4, Interstitial; retinol Binding Protein 4; retinol-Binding Protein 4, Plasma; Plasma retinol-Binding Protein; retinol Binding Protein 4, Plasma; retinol-Binding Protein 4; retinol-Binding Protein; PRBP; MCOPCB10; RBP; RDCCAS

Species:

Rat

Source:

HEK293

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1

RBP3 Protein, Human (His)

1 Cited Publications

Cat. No.: HY-P71104

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: RBP3; retinol-Binding Protein 3; retinol Binding Protein 3; retinol-Binding Protein 3, Interstitial; IRBP; retinol Binding Protein 3, Interstitial; Interphotoreceptor Retinoid-Binding Protein; Interstitial retinol-Binding Protein 3; D10S64; Interstitial R

Species:

Human

Source:

E. coli

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Vitamin A

Cat. No.: HY-B1342

CAS No.: 68-26-8

Synonyms: Vitamin A1; all-trans-retinol

Category:

Human Gut Microbiota Metabolites Natural Products Microorganisms Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Environmental Pollutants Endogenous Metabolite

Vitamin A (Vitamin A1) is an endogenous metabolite.

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9-cis-Retinal

Cat. No.: HY-W009310

CAS No.: 514-85-2

Category:

Terpenoids Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Organoid

9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with K_ds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids .

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all-trans-Anhydro Retinol

Cat. No.: HY-N7495

CAS No.: 1224-78-8

Synonyms: Anhydrovitamin A

Category:

Terpenoids Metabolic Disease Diterpenoids Endogenous metabolite Disease Research Fields

Target:

Drug Metabolite

all-trans-Anhydro Retinol (Anhydrovitamin A) is an orally active degradation product formed by the dehydration of vitamin A alcohol and its esters under conditions such as acidic catalysis or hydroxylic solvents, with a biological activity only 0.4% of that of Vitamin A (HY-B1342). In rats, all-trans-Anhydro Retinol can be metabolized into hydroxy derivatives and their esters, but it cannot be converted into Vitamin A (HY-B1342) and has a low storage capacity in the body .

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11-cis-Retinal

Cat. No.: HY-116711

CAS No.: 564-87-4

Synonyms: 11-cis Retinaldehyde; 11-cis Vitamin A aldehyde

Category:

Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:

Drug Derivative Endogenous Metabolite

11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model .

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Emixustat hydrochloride

Cat. No.: HY-19720A

CAS No.: 1141934-97-5

Synonyms: ACU-4429 hydrochloride

Target:

RPE65

Research Areas:

Metabolic Disease

Emixustat (ACU-4429) hydrochloride is an orally active RPE65 inhibitor with an IC₅₀ value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) .

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