277 Results for "

rhizome

" in MedChemExpress (MCE) Product Catalog:
Products (277)

277 Results for "rhizome" in MCE Product Catalog:

6
Atractylenolide I
Atractylenolide I
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6 Publications Verification
Cat. No.: HY-N0201
CAS No.: 73069-13-3
Category:  

Plant Terpenoids Atractylodes macrocephala Koidz. Extract Sesquiterpenes Compositae/Asteraceae Extract Disease Research Fields Cancer

Target:  

TNF Receptor Toll-like Receptor (TLR) JAK STAT

Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.
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6
Paris saponin VII
Paris saponin VII
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6 Publications Verification
Cat. No.: HY-N3584
CAS No.: 68124-04-9
Synonyms: Chonglou Saponin VII
Category:  

Plant Liliaceae Extract Trillium tschonoskii Maxim. Extract Disease Research Fields Cancer Steroids

Target:  

Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
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5
Sinapinic acid
Sinapinic acid
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5 Cited Publications
Cat. No.: HY-W009732
CAS No.: 530-59-6
Synonyms: Sinapic acid
Category:  

Plant Monophenols Simple Phenylpropanols Metabolic Disease Phenols Phenylpropanoids Other Families Extract Disease Research Fields

Target:  

HDAC Angiotensin-converting Enzyme (ACE) Reactive Oxygen Species (ROS) Apoptosis

Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM , and also inhibits ACE-I activity . Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells . Sinapinic acid shows antioxidant and antidiabetic activities . Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats .
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5
Alisol A
Alisol A
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5 Cited Publications
Cat. No.: HY-N0853
CAS No.: 19885-10-0
Category:  

Alisma plantago-aquatica Linn. Extract Triterpenes Plant Terpenoids Other Diseases Disease Research Fields Alismataceae Extract

Target:  

AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related

Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .
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5
8-Gingerol
8-Gingerol
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5 Cited Publications
Cat. No.: HY-N0447
CAS No.: 23513-08-8
Category:  

Plant Monophenols Zingiberaceae Extract Phenols Zingiber officinale Roscoe Extract Disease Research Fields Inflammation/Immunology Cancer

Target:  

TRP Channel Bacterial Apoptosis Autophagy STAT PERK EGFR PI3K Akt mTOR Caspase MMP

8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC50 value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.
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4
(+)-Afzelechin
(+)-Afzelechin
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4 Cited Publications
Cat. No.: HY-N2821
CAS No.: 2545-00-8
Category:  

Saxifragaceae Extract Plant Flavonoids Flavanols Metabolic Disease Phenols Polyphenols Disease Research Fields

Target:  

Glycosidase

(+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an alpha-glucosidase activity inhibitor with an ID50 (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin can delay the absorption of carbohydrates in food to suppress postprandial hyperglycemia and hyperinsulinemia .
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4
10-Gingerol
10-Gingerol
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4 Cited Publications
Cat. No.: HY-N0448
CAS No.: 23513-15-7
Category:  

Plant Monophenols Zingiberaceae Extract Ketones, Aldehydes, Acids Phenols Zingiber officinale Roscoe Extract Disease Research Fields Inflammation/Immunology

Target:  

Free Radical Scavengers AMPK Reactive Oxygen Species (ROS) Akt PI3K Interleukin Related TNF Receptor Apoptosis

10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC50 value of 10.47 μM against DPPH radical, an IC50 value of 1.68 μM against superoxide radical and an IC50 value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol can be used in research on various common cancers such as ovarian cancer and colon cancer, as well as colitis and neurodegenerative diseases .
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3
Atractylenolide III
Atractylenolide III
0 Images
3 Cited Publications
Cat. No.: HY-N0203
CAS No.: 73030-71-4
Synonyms: ICodonolactone; 8β-Hydroxyasterolide
Category:  

Plant Terpenoids Atractylodes macrocephala Koidz. Extract Sesquiterpenes Compositae/Asteraceae Extract Disease Research Fields Cancer

Target:  

Apoptosis

Atractylenolide III (ICodonolactone) is the main component of Atractylodes rhizome and has the activity of inducing apoptosis in lung cancer cells. Atractylenolide III is an orally active gastroprotective agent .
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3
Atractylodin
Atractylodin
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3 Cited Publications
Cat. No.: HY-N0238
CAS No.: 55290-63-6
Synonyms: Atractydin
Category:  

Infection Natural Products Plant Atractylodes lancea (Thunb.) DC Extract Compositae/Asteraceae Extract Disease Research Fields

Target:  

Insecticide

Atractylodin (Atractydin) is an orally active active ingredient obtained from the rhizome of Atractylodes lancea and A. chinensis. Atractylodin is a natural insecticide. Atractylodin has anti-inflammatory activity .
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2
Timosaponin BII
Timosaponin BII
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2 Cited Publications
Cat. No.: HY-N0812
CAS No.: 136656-07-0
Synonyms: Prototimosaponin A III
Category:  

Plant Neurological Disease Liliaceae Extract Anemarrhena asphodeloides Bunge Extract Disease Research Fields Inflammation/Immunology Steroids

Target:  

Amyloid-β

Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .
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2
β-Eudesmol
β-Eudesmol
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2 Cited Publications
Cat. No.: HY-N6018
CAS No.: 473-15-4
Category:  

Plant Terpenoids Sesquiterpenes Metabolic Disease Other Families Extract Disease Research Fields

Target:  

Caspase TNF Receptor SOD Reactive Oxygen Species (ROS)

β-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. β-Eudesmol is a neostigmine antagonist. β-Eudesmol can antagonize neostigmine-induced neuromuscular failure. β-Eudesmoll can be used in the study of sepsis diseases. β-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea .
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2
Dichotomitin
Dichotomitin
0 Images
2 Cited Publications
Cat. No.: HY-N2120
CAS No.: 88509-91-5
Category:  

Plant Flavonoids Other Diseases Phenols Polyphenols Iridaceae Extract Disease Research Fields Belamcanda chinensis (Linn.) Redouté Extract Isoflavones

Target:  

Reactive Oxygen Species (ROS) SOD RUNX

Dichotomitin is an isoflavonoid compound isolated from the rhizomes of Belamcanda chinensis. Dichotomitin exhibits antioxidant activity, alleviates oxidative stress, reduces intracellular reactive oxygen species (ROS) levels, and upregulates the expression of SOD1, SOD2 and CAT. Dichotomitin increases ALP activity while upregulating the expression of RUNX2, OPN and OCN. Dichotomitin has antitussive activity and helps improve symptoms of upper respiratory tract infections .
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1
Orcinol gentiobioside
Orcinol gentiobioside
0 Images
1 Cited Publications
Cat. No.: HY-N4123
CAS No.: 164991-86-0
Category:  

Plant Monophenols Other Diseases Amaryllidaceae Extract Phenols Hypoxidaceae Extract Disease Research Fields Curculigo orchioides Gaertn. Extract

Target:  

Others

Orcinol gentiobioside (compound 4) is a natural product isolated from the rhizomes of C. breviscapa .
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1
Anemarrhenasaponin A2
Anemarrhenasaponin A2
0 Images
1 Cited Publications
Cat. No.: HY-N7614
CAS No.: 117210-12-5
Synonyms: Schidigerasaponin F2; Timosaponin AII
Category:  

Cardiovascular Disease Plant Liliaceae Extract Anemarrhena asphodeloides Bunge Extract Disease Research Fields Steroids

Target:  

Others

Anemarrhenasaponin A2 (Schidigerasaponin F2) is a steroidal saponin isolated from the rhizomes of Anemarrhena asphodeloides. Anemarrhenasaponin A2 inhibits ADP-induced platelet aggregation .
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1
3-O-Methylgalangin
3-O-Methylgalangin
0 Images
1 Cited Publications
Cat. No.: HY-N4167
CAS No.: 6665-74-3
Synonyms: Galangin 3-methyl ether; 3-Methylgalangin
Category:  

Infection Flavonols Plant Flavonoids Zingiberaceae Extract Phenols Polyphenols Disease Research Fields Alpinia officinarum Hance Extract

Target:  

Bacterial

3-O-Methylgalangin (Galangin 3-methyl ether) is a natural flavonoid compound from the rhizome of Alpinia officinarum (AO) with antibacterial activities, which also inhibits pancreatic lipase .
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1
Isocurcumenol
Isocurcumenol
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1 Cited Publications
Cat. No.: HY-N4121
CAS No.: 24063-71-6
Category:  

Plant Terpenoids Sesquiterpenes Other Families Extract Disease Research Fields Cancer

Target:  

Estrogen Receptor/ERR Apoptosis

Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively .
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1
Dactylorhin A
Dactylorhin A
0 Images
1 Cited Publications
Cat. No.: HY-125531
CAS No.: 256459-34-4
Purity:  98.22%
Category:  

Plant Orchidaceae Extract Ketones, Aldehydes, Acids Other Diseases Bletilla striata (Thunb. ex Murray) Rchb. f. Extract Disease Research Fields

Target:  

Biochemical Assay Reagents

Dactylorhin A is a glucoside and succinate derivative ester inhibitor that can be found in Bletilla striata tubers and Gymnadenia conopsea rhizomes, with activity against nitric oxide production in macrophage cells .Dactylorhin A suppresses lipopolysaccharide-induced nitric oxide generation via a cytotoxicity-independent pathway .
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1
Diacetoxy-6-gingerdiol
Diacetoxy-6-gingerdiol
0 Images
1 Cited Publications
Cat. No.: HY-133865
CAS No.: 143615-75-2
Purity:  98.01%
Category:  

Plant Monophenols Zingiberaceae Extract Other Diseases Phenols Zingiber officinale Roscoe Extract Disease Research Fields

Target:  

Interleukin Related

Diacetoxy-6-gingerdiol is a gingerol isolated with anti-inflammatory and antioxidant effects, which is found in the dichloromethane extract of rhizomes of ginger (Zingiber officinale Roscoe). Diacetoxy-6-gingerdiol protects the extracellular matrix of nucleus pulposus cells and ameliorates intervertebral disc degeneration by inhibiting the IL-1β-mediated NLRP3 pathway .
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Hederasaponin B
Hederasaponin B
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1 Cited Publications
Cat. No.: HY-N0306
CAS No.: 36284-77-2
Category:  

Infection Triterpenes Plant Terpenoids Disease Research Fields Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Extract Araliaceae Extract

Target:  

Enterovirus

Hederasaponin B is an orally active oleanane-type triterpenoid saponin and antiviral agent. Hederasaponin B is isolated from the leaves of Acanthopanax senticosus, Hedera nepalensis var. sinensis, and the rhizomes of Souliea vaginata. Hederasaponin B inhibits the expression of the viral capsid protein VP2 and attenuates virus-induced cytopathic effects. Hederasaponin B exhibits activity against Enterovirus 71 subtypes C3 and C4a. Hederasaponin B shows no hepatoprotective effect against CCl4-induced hepatocyte injury. Hederasaponin B is used in research on hand, foot, and mouth disease .
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2-Heptanol
2-Heptanol
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Cat. No.: HY-W015879
CAS No.: 543-49-7
Category:  

Natural Products Plant Zingiberaceae Extract Curcuma longa Extract Disease Research Fields Inflammation/Immunology

Target:  

Environmental Pollutants Bacterial

2-Heptanol is one of the chemical compounds identified in turmeric and turmeric rhizome essential oil. 2-Heptanol can speed up amino acid metabolism and slow down membrane transport, exhibiting antibacterial activity. The rhizome essential oil has good antibacterial and antioxidant properties .
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