45 Results for "

rodent brain

" in MedChemExpress (MCE) Product Catalog:
Products (45)

45 Results for "rodent brain" in MCE Product Catalog:

4
Regadenoson
Regadenoson
0 Images
4 Cited Publications
Cat. No.: HY-A0168
CAS No.: 313348-27-5
Synonyms: CVT-3146
Target:  

Adenosine Receptor

Research Areas:  

Cardiovascular Disease Cancer

Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS .
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JNJ-55308942
JNJ-55308942
0 Images
3 Cited Publications
Cat. No.: HY-123857
CAS No.: 2166558-11-6
Purity:  99.82%
Target:  

P2X Receptor

Research Areas:  

Neurological Disease Inflammation/Immunology

JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1β release from adult rodent brain .
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RO5256390
RO5256390
0 Images
3 Cited Publications
Cat. No.: HY-12700
CAS No.: 1043495-96-0
Purity:  98.75%
Target:  

Trace Amine-associated Receptor (TAAR)

Research Areas:  

Neurological Disease

RO5256390 is an orally effective trace amine associated receptor 1 (TAAR1) agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine (HY-14541). RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP (HY-B2176)-induced TNF secretion in mouse bone marrow-derived macrophages .
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2
Talampanel
Talampanel
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2 Cited Publications
Cat. No.: HY-15079
CAS No.: 161832-65-1
Purity:  99.77%
Synonyms: GYKI-53773; LY-300164
Target:  

iGluR Apoptosis

Research Areas:  

Neurological Disease Cancer

Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity . Talampanel (IVAX) has neuroprotective effects in rodent stroke models . Talampanel attenuates caspase-3 dependent apoptosis in mouse brain .
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TAK-418
TAK-418
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2 Cited Publications
Cat. No.: HY-138830
CAS No.: 1818252-53-7
Purity:  99.81%
Target:  

Histone Demethylase

Research Areas:  

Neurological Disease

TAK-418 is an orally active, blood-brain barrier-penetrant LSD1 inhibitor with a human IC50 of 2.9 nM. TAK-418 irreversibly inhibits LSD1 by forming a compact flavin-FAD adduct with the catalytic domain FAD, blocking the demethylation of H3K4me1/2 and H3K9me1/2 without disrupting the LSD1-GFI1B interaction. TAK-418 restores normally dysregulated brain gene expression and DNA methylation, increases H3K4me1/2/3 and H3K9me2 at the Ucp2 locus, and induces Ucp2 mRNA expression. TAK-418 rescues defective H3K4 histone modifications, normalizes adult neurogenesis, and improves recognition memory, social behavior, and cognition in rodent models. TAK-418 can be used in research related to neurodevelopmental disorders, Alzheimer's disease, and autism spectrum disorders .
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1
4'-O-Methylpyridoxine
4'-O-Methylpyridoxine
0 Images
1 Cited Publications
Cat. No.: HY-N8157
CAS No.: 1464-33-1
Category:  

Alkaloids Ginkgoaceae Extract Other Diseases Pyridine Alkaloids 500 - Internal Server Error | MedChemExpress

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