616 Results for "

rooting percentage

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Triptolide

78 Publications Verification

Cat. No.: HY-32735

CAS No.: 38748-32-2

Synonyms: PG490

Category:

Anti-aging Celastraceae Extract Tripterygium wilfordii Hook. f. Extract Biological Pesticide Research Agricultural Research Plant Terpenoids Diterpenoids Disease Research Fields Cancer

Target:

Environmental Pollutants NF-κB Apoptosis

Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

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Cryptotanshinone

47 Cited Publications

Cat. No.: HY-N0174

CAS No.: 35825-57-1

Synonyms: Cryptotanshinon; Tanshinone c

Category:

Quinones Plant Salvia miltiorrhiza Bunge Extract Disease Research Fields Naphthalene Quinones Cancer Labiatae Extract

Target:

STAT Autophagy

Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC₅₀ of 4.6 μM.

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Tanshinone IIA

40 Cited Publications

Cat. No.: HY-N0135

CAS No.: 568-72-9

Synonyms: Dan Shen ketone

Category:

Quinones Plant Terpenoids Diterpenoids Salvia miltiorrhiza Bunge Extract Disease Research Fields Naphthalene Quinones Cancer Labiatae Extract

Target:

VEGFR

Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

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Isoliquiritigenin

38 Cited Publications

Cat. No.: HY-N0102

CAS No.: 961-29-5

Synonyms: GU17; ISL; Isoliquiritigen; SJ000286237

Category:

Leguminosae/Fabaceae Extract Glycyrrhiza uralensis Fisch. Extract Infection Plant Flavonoids Chalcones Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

Aldose Reductase Influenza Virus Autophagy Apoptosis

Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC₅₀ of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC₅₀ of 24.7 μM.

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Puerarin

34 Cited Publications

Cat. No.: HY-N0145

CAS No.: 3681-99-0

Category:

Leguminosae/Fabaceae Extract Plant Flavonoids Pueraria edulis Pampan. Extract Phenols Polyphenols Disease Research Fields Cancer Isoflavones

Target:

5-HT Receptor

Puerarin is an isoflavone extracted from Pueraria root and is a 5-HT2C receptor antagonist. Puerarin inhibits the dorsal motor nucleus of the vagus (DMV)-vagus nerve pathway, which in turn leads to decreased fat absorption .

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Ginsenoside Rb1

18 Cited Publications

Cat. No.: HY-N0039

CAS No.: 41753-43-9

Synonyms: Gypenoside III

Category:

Triterpenes Plant Terpenoids Panax ginseng C. A. Meyer Extract Disease Research Fields Cancer Araliaceae Extract

Target:

Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV

Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

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Sanguinarine chloride

17 Cited Publications

Cat. No.: HY-N0052A

CAS No.: 5578-73-4

Synonyms: Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride

Category:

Alkaloids Plant Pyridine Alkaloids Sanguinaria canadensis Extract Disease Research Fields Papaveraceae Extract Cancer

Target:

Apoptosis Autophagy Bacterial Parasite

Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

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Vacuolin-1

14 Cited Publications

Cat. No.: HY-118630

CAS No.: 351986-85-1

Purity: 98.93%

Target:

PIKfyve Autophagy

Research Areas:

Cancer

Vacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Vacuolin-1 blocks the Ca ²⁺-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation. Vacuolin-1 can induce vacuole formation and increase the percentage of enucleated cells .

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Paeonol

13 Cited Publications

Cat. No.: HY-N0159

CAS No.: 552-41-0

Category:

Plant Paeoniaceae Extract Monophenols Neurological Disease Paeonia suffruticosa Andr. Extract Phenols Disease Research Fields Cancer

Target:

Monoamine Oxidase Autophagy

Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC₅₀ of 54.6 μM and 42.5 μM, respectively.

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Licochalcone B

13 Cited Publications

Cat. No.: HY-N0373

CAS No.: 58749-23-8

Category:

Leguminosae/Fabaceae Extract Plant Flavonoids Chalcones Glycyrrhiza uralensis Fisch. Extract

Target:

Amyloid-β Apoptosis NOD-like Receptor (NLR)

Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .

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Higenamine

12 Cited Publications

Cat. No.: HY-N2037

CAS No.: 5843-65-2

Synonyms: Norcoclaurine; Demethyl-Coclaurine

Category:

Alkaloids Plant Phenols Polyphenols Aconitum carmichaeli Debx. Extract Disease Research Fields Isoquinoline Alkaloids Endocrinology Ranunculaceae Extract

Target:

MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis

Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC₅₀=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .

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Albiflorin

9 Cited Publications

Cat. No.: HY-N0037

CAS No.: 39011-90-0

Category:

Other Monoterpenes Plant Paeoniaceae Extract Terpenoids Paeonia lactiflora Pall. Extract Disease Research Fields Inflammation/Immunology

Target:

Reactive Oxygen Species (ROS)

Albiflorin, a major constituent contained in peony root, is a brain-penetrant monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects .

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Periplocin

8 Cited Publications

Cat. No.: HY-N1381

CAS No.: 13137-64-9

Category:

Asclepiadaceae Extract Plant Periploca sepium Bunge Extract Disease Research Fields Inflammation/Immunology Steroids

Target:

Apoptosis

Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

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MRS 1523

6 Cited Publications

Cat. No.: HY-121119

CAS No.: 212329-37-8

Purity: 99.97%

Target:

Adenosine Receptor Calcium Channel

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

MRS 1523 is a potent and selective adenosine A₃ receptor antagonist with K_i values of 18.9 nM and 113 nM for human and rat A₃ receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A₁ and A_2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons .

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(20R)-Ginsenoside Rg3

5 Cited Publications

Cat. No.: HY-N1376

CAS No.: 38243-03-7

Synonyms: (20R)-Propanaxadiol; R-ginsenoside Rg3

Category:

Triterpenes Plant Terpenoids Panax ginseng C. A. Meyer Extract Disease Research Fields Cancer Araliaceae Extract

Target:

Others

(20R)-ginsenoside Rg3 ((20R)-Propanaxadiol), one of the active compounds present in ginseng root, inhibits angiogenesis, and has anti-carcinogenic and antimetastatic effects .

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Licochalcone D

5 Cited Publications

Cat. No.: HY-N4187

CAS No.: 144506-15-0

Category:

Leguminosae/Fabaceae Extract Glycyrrhiza uralensis Fisch. Extract Metabolic Disease Plant Flavonoids Chalcones Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

NF-κB Apoptosis Reactive Oxygen Species (ROS)

Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties .

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Zinpyr-1

4 Cited Publications

Cat. No.: HY-D0155

CAS No.: 288574-78-7

Zinpyr-1 is a zinc-responsive fluorescent indicator and a membrane-permeable metal-binding probe. Zinpyr-1 forms a complex with Mn ²⁺ ions and generates a fluorescence turn-on signal. Zinpyr-1 binds to free zinc ions in serum, enabling quantitative detection of free zinc concentration. Zinpyr-1 produces fluorescence signals reflecting the relative zinc concentration in plant root cells, localizes to specific layers of plant root cells, and can be used to support analyses related to plant zinc transporter mutations and homeostasis .

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Tenuigenin

4 Cited Publications

Cat. No.: HY-N0802

CAS No.: 2469-34-3

Synonyms: Senegenin

Category:

Triterpenes Plant Polygala tenuifolia Willd. Extract Terpenoids Polygalaceae Extract Disease Research Fields Inflammation/Immunology

Target:

NF-κB Bacterial

Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect .

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Fraxinellone

4 Cited Publications

Cat. No.: HY-N0242

CAS No.: 28808-62-0

Category:

Rutaceae Extract Plant Terpenoids Sesquiterpenes Dictamnus dasycarpus Turcz. Extract Disease Research Fields Inflammation/Immunology

Target:

PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT

Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1 .

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Kushenol A

4 Cited Publications

Cat. No.: HY-N2278

CAS No.: 99217-63-7

Synonyms: Leachianone E

Category:

Leguminosae/Fabaceae Extract Sophora flavescens Aiton Extract Plant Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Cancer

Target:

Tyrosinase Glycosidase

Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC₅₀ and K_ivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM; K_i: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .

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