15

TPPU

15 Publications Verification

Cat. No.: HY-101294

CAS No.: 1222780-33-7

Purity: 99.10%

Target:

Epoxide Hydrolase

Research Areas:

Inflammation/Immunology

TPPU is a soluble epoxide hydrolase (sEH) inhibitor with IC₅₀ values of 37 and 3.7 nM for monkey and human sEH, respectively.

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3

AUDA

3 Cited Publications

Cat. No.: HY-108570

CAS No.: 479413-70-2

Purity: ≥98.0%

Target:

Epoxide Hydrolase

Research Areas:

Inflammation/Immunology

AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC₅₀s of 18 and 69 nM for the mouse and human sEH, respectively . AUDA has anti-inflammatory activity .

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2

GSK2256294A

2 Cited Publications

Cat. No.: HY-19644

CAS No.: 1142090-23-0

Synonyms: GSK 2256294

Target:

Epoxide Hydrolase

Research Areas:

Cardiovascular Disease

GSK2256294A (GSK 2256294) is a selective and orally active inhibitor of soluble epoxide hydrolase (sEH). GSK2256294A inhibits recombinant human sEH, rat sEH orthologs and murine sEH orthologs with IC₅₀s of 27, 61 and 189 pM, respectively. GSK2256294A can be used for the research of chronic obstructive pulmonary disease (COPD) and cardiovascular disease .

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2

trans-AUCB

2 Cited Publications

Cat. No.: HY-113974

CAS No.: 885012-33-9

Purity: 98.16%

Synonyms: t-AUCB

Target:

Epoxide Hydrolase

Research Areas:

Cancer

trans-AUCB (t-AUCB) is a potent, orally active and selective soluble epoxide hydrolase (sEH) inhibitor with IC₅₀s of 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively. trans-AUCB has anti-glioma activity .

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1

Diflapolin

1 Cited Publications

Cat. No.: HY-128171

CAS No.: 724453-98-9

Purity: 99.67%

Target:

FLAP Epoxide Hydrolase

Research Areas:

Inflammation/Immunology

Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC₅₀s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC₅₀=20?nM) .

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1

EC5026

1 Cited Publications

Cat. No.: HY-135653

CAS No.: 1809885-32-2

Purity: 98.13%

Synonyms: BPN-19186

Target:

Epoxide Hydrolase

Research Areas:

Neurological Disease

EC5026 (BPN-19186) is a first-in-class, non-opioid and orally active soluble Epoxide Hydrolase (sEH) inhibitor. EC5026 shows efficacy for inflammatory and neuropathic pain .

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1

CUDA

1 Cited Publications

Cat. No.: HY-121538

CAS No.: 479413-68-8

Purity: ≥98.0%

Target:

Epoxide Hydrolase PPAR

Research Areas:

Cardiovascular Disease

CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC₅₀s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively . CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease .

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1

AR-9281

1 Cited Publications

Cat. No.: HY-111151

CAS No.: 913548-29-5

Purity: 99.69%

Synonyms: APAU

Target:

Epoxide Hydrolase

Research Areas:

Infection Cardiovascular Disease Metabolic Disease

AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC₅₀ values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes .

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