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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
63 Results for "
secretory activity
" in MedChemExpress (MCE) Product Catalog:
Products (63)
63 Results for "secretory activity" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: LY315920
Target:
Research Areas:
Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .
12
12 Publications Verification
Synonyms: LY315920 sodium
Target:
Research Areas:
Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .
8
8 Cited Publications
Synonyms: M&B 9302 hydrochloride
Clorgyline hydrochloride (M&B 9302 hydrochloride) is a selective, irreversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier and exhibits activity against the 5-HT Receptor at very high doses. Clorgyline hydrochloride regulates monoamine neurotransmitter levels, the release of dopamine and acetylcholine, the uptake and effects of Tyramine (HY-W007606), noradrenergic function, circadian locomotor activity rhythms, feeding behavior, and body weight. Clorgyline hydrochloride induces tumor-suppressive transcriptional programs, secretory differentiation, androgen signaling regulation, Bcl-2 expression, and radioprotective effects in non-malignant cells. Clorgyline hydrochloride is used in the research of high-grade prostate cancer, Huntington's disease, major affective disorder, radiation-induced normal tissue toxicity, and obesity .
8
Research Areas:
Clorgyline (M&B 9302) is a selective, irreversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier and exhibits activity against the 5-HT Receptor at very high doses. Clorgyline regulates monoamine neurotransmitter levels, the release of dopamine and acetylcholine, the uptake and effects of Tyramine (HY-W007606), noradrenergic function, circadian locomotor activity rhythms, feeding behavior, and body weight. Clorgyline induces tumor-suppressive transcriptional programs, secretory differentiation, androgen signaling regulation, Bcl-2 expression, and radioprotective effects in non-malignant cells. Clorgyline is used in the research of high-grade prostate cancer, Huntington's disease, major affective disorder, radiation-induced normal tissue toxicity, and obesity .
5
Target:
Research Areas:
Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
5
5 Cited Publications
Cat. No.: HY-17507A
CAS No.: 138786-67-1
Synonyms: BY1023 sodium; SKF96022 sodium
Target:
Research Areas:
Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
5
5 Cited Publications
Cat. No.: HY-17507B
CAS No.: 164579-32-2
Synonyms: BY1023 sodium hydrate; SKF96022 sodium hydrate
Target:
Research Areas:
Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
4
4 Cited Publications
Cat. No.: HY-N8211
CAS No.: 94987-09-4
4
4 Cited Publications
Cat. No.: HY-P70508
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL1; Neutrophil-Activating Protein 3; Prev. GRO1; Fibroblast secretory Protein; Prev. MGSA; C-X-C Motif Chemokine 1; Prev. FSP; GRO-Alpha(1-73); SCYB1; GRO1 Oncogene (Melanoma Growth-Stimulating activity); NAP-3; Melanoma Growth Stimulatory activity Alpha; MGSA-A; Melanoma Growth Stimulatory activity; GROa; MGSA Alpha; Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating activity, Alpha); GROA; GRO1 Oncogene (Melanoma Growth Stimulating activity, Alpha); GRO; Melanoma Growth Stimulating activity, Alpha; C-X-C Motif Chemokine Ligand 1; Growth-Regulated Alpha Protein
Species:
Human
Source:
HEK293
2
Category:
Umbelliferae/Apiaceae Extract Flavonols Plant Flavonoids Coriandrum sativum Linn. Extract Phenols Polyphenols Disease Research Fields Inflammation/Immunology
Target:
2
2 Cited Publications
Cat. No.: HY-P7188
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL1; Neutrophil-Activating Protein 3; Prev. GRO1; Fibroblast secretory Protein; Prev. MGSA; C-X-C Motif Chemokine 1; Prev. FSP; GRO-Alpha(1-73); SCYB1; GRO1 Oncogene (Melanoma Growth-Stimulating activity); NAP-3; Melanoma Growth Stimulatory activity Alp
Species:
Mouse
Source:
E. coli
1
Target:
Research Areas:
PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC50=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway .
1
1 Cited Publications
Cat. No.: HY-P71110
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TIMP1; Collagenase Inhibitor; Prev. CLGI; EPA; Prev. TIMP; Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating activity, Collagenase Inhibitor); Tissue Inhibitor Of Metalloproteinases 1; Epididymis secretory Sperm Binding Protein; Metalloprote
Species:
Mouse
Source:
HEK293
Category:
Vitex negundo Linn. Extract Natural Products Plant Verbenaceae Extract Disease Research Fields Inflammation/Immunology
Target:
Target:
Research Areas:
KH064, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 29 nM for human nonpancreatic secretory PLA2 isoform IIa (hnpsPLA2-IIa). KH064 has anti-inflammatory activity .
Cat. No.: HY-P4060
CAS No.: 59763-91-6
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Research Areas:
Cat. No.: HY-120078
CAS No.: 1845753-81-2
Target:
Research Areas:
AZD2716 is an orally active secretory phospholipase A2 (sPLA2) inhibitor. AZD2716 inhibits human GIIA sPLA2 (IC50=10 nM), human GV sPLA2 (IC50=40 nM), human GX sPLA2 (IC50=400 nM), snake venom sPLA2 (IC50=2 pM), and snake (Bothrops jararacussu) Lys49-PLA2-like toxin (Kd=110 μM). AZD2716 inhibits sPLA2 isoforms IIa, V, X, snake venom sPLA2s, and snake venom Lys49-PLA2-like toxin myotoxic activity via hydrophobic channel binding. AZD2716 suppresses GIIA sPLA2 production, neutralizes snake venom-induced myotoxicity, and improves survival in envenomed mice. AZD2716 can be used for the research of coronary artery disease, atherosclerosis, and snakebite envenoming .
Category:
Alkaloids Plant Zygophyllaceae Extract Nitrariaceae Extract Other Alkaloids Disease Research Fields Inflammation/Immunology Peganum harmala L. Extract
Target:
Cat. No.: HY-17507AR
CAS No.: 138786-67-1
Synonyms: BY1023 sodium (Standard); SKF96022 sodium (Standard)
Research Areas:
Pantoprazole (sodium) (Standard) is the analytical standard of Pantoprazole (sodium). This product is intended for research and analytical applications. Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
Cat. No.: HY-176130
CAS No.: 3115333-82-6
Target:
Research Areas:
MRL828 is a heterobifunctional molecule that targets aggregated tau protein. As an autophagy-targeting chimera (ATTEC), MRL828 selectively labels aggregated tau protein for clearance via the autophagy (autophagy)-lysosome pathway. The activity of MRL828 depends on autophagosomes rather than lysosomes, and it induces autophagosome-dependent secretion. MRL828 acts as an intracellular aggregate inhibitor and a secretory autophagy inducer, reducing intracellular levels of aggregated tau protein through autophagosome-dependent secretory autophagy instead of lysosomal degradation. MRL828 can be used in the research of neurodegenerative diseases such as Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
