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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
sedative activity
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "sedative activity" in MCE Product Catalog:
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(S)-(-)-Propranolol hydrochloride is the active isomer of Propranolol (HY-B0573B), with 98-fold greater activity than (R)-(+)-Propranolol. (S)-(-)-Propranolol hydrochloride produces antinociception-related phenotypes in mouse models, accompanied by sedative and ataxic side effects. (S)-(-)-Propranolol hydrochloride can be used in research related to hypertension, myocardial infarction, and pain .
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1 Cited Publications
Cat. No.: HY-N2059
CAS No.: 11031-45-1
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Santalum album Linn. Terpenoids Sesquiterpenes Plants Other Families Extract Disease Research Fields Cancer Santalaceae Extract
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Levomepromazine (Methotrimeprazine) is an orally active antipsychotic compound and Ca 2+ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca 2+ levels. Levomepromazine has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine can induce adaptive ER stress and autophagy. In addition, Levomepromazine has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine can be used in the study psychiatric disorders and relieving nausea and vomiting .
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Levomepromazine maleate (Methotrimeprazine maleate) is an orally active antipsychotic compound and Ca 2+ release inducer. Levomepromazine maleate inhibits SERCA pump and induces an increase in cytoplasmic Ca 2+ levels. Levomepromazine maleate has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine maleate can induce adaptive ER stress and autophagy. In addition, Levomepromazine maleate has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine maleate can be used in the study psychiatric disorders and relieving nausea and vomiting .
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(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy .
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1 Cited Publications
Cat. No.: HY-W008645
CAS No.: 131733-92-1
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NCS-382 (sodium) is a potent GABA receptor antagonist. NCS-382 (sodium) has anti-sedative and anti-hypnotic activities and can be used in research related to neurological diseases .
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1 Cited Publications
Cat. No.: HY-A0022A
CAS No.: 63302-99-8
Synonyms: Azafen monohydrate; Pipofezin dihydrochloride monohydrate; Pipofezine dihydrochloride monohydrate
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Azaphen dihydrochloride monohydrate is an orally active tricyclic antidepressant that inhibits the reuptake of serotonin and monoamines, regulates the 5-HT2c receptor, and exerts sedative, antidepressant and anxiolytic effects. Azaphen dihydrochloride monohydrate increases the bioavailability of serotonin in the synaptic cleft, does not block muscarinic receptors or affect monoamine oxidase activity, and binds to the human serotonin transporter via salt bridges, π-stacking, π-cation and hydrophobic interactions. Azaphen dihydrochloride monohydrate can be used in studies related to depression .
Cat. No.: HY-W013507
CAS No.: 39924-52-2
Cat. No.: HY-N8290
CAS No.: 65725-11-3
Synonyms: Lactucopicrin
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Monophenols Genista quadriflora Munby Terpenoids Sesquiterpenes Phenols Plants Compositae Extract
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CL 218872 is an orally active and selective ligand for the benzodiazepine receptor subtype BZ1. CL 218872 exhibits anxiolytic, sedative and anticonvulsant activities. CL 218872 can be used in researches of anxiety related disorders and epilepsy .
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Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis .
Synonyms: SENS-111
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Seliforant (SENS-111) is a selective, orally active histamine H4 receptor antagonist. Seliforant inhibits the sustained activity of vestibular neurons and modulates vestibular-related responses. Seliforant reduces spontaneous nystagmus in rats with excitotoxic acute unilateral vestibular loss. Seliforant shows no sedative effect. Seliforant can be used in research related to acute unilateral vestibular loss, vestibular dysfunction, and acute unilateral vestibular lesions .
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Trimetozine is an Antifungal agent and sedative. Trimetozine exhibits antibacterial activity against Candida albicans, Candida glabrata, and Miconazole (HY-B0454)-resistant Candida glabrata cultures. Trimetozine exerts a sedative effect. Trimetozine can be used in research related to candidiasis and anxiety disorders .
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Pheneturide (Ethylphenacemide; M 551) is an orally active anticonvulsant. Pheneturide is a decarboxylation product of 5-ethyl-5-phenylbarbituric acid, with antiepileptic and central inhibitory effects. Pheneturide has protective effects against both MES tonic convulsions and Metrazol clonic convulsions. Pheneturide prolongs sedative-induced sleep, increases spontaneous locomotor activity, and inhibits fighting behavior. Pheneturide can be used in epilepsy-related research .
Cat. No.: HY-W013507R
CAS No.: 39924-52-2
Cat. No.: HY-A0022
CAS No.: 24853-80-3
Synonyms: Azafen; Pipofezin hydrochloride; Pipofezine hydrochloride
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
