3

Flibanserin

3 Cited Publications

Cat. No.: HY-A0095

CAS No.: 167933-07-5

Synonyms: BIMT-17; BIMT-17BS

Target:

5-HT Receptor Dopamine Receptor

Research Areas:

Neurological Disease Cancer

Flibanserin (BIMT-17; BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K_i values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an K_i value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research ^- .

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3

Estradiol-d4

3 Cited Publications

Cat. No.: HY-B0141S1

CAS No.: 66789-03-5

Synonyms: β-Estradiol-d₄; 17β-Estradiol-d₄; 17β-Oestradiol-d₄

Estradiol-d₄ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

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3

Flibanserin hydrochloride (propan-2-ol) hydrate

3 Cited Publications

Cat. No.: HY-A0095A

Synonyms: BIMT-17 hydrochloride (propan-2-ol) hydrate; BIMT-17BS hydrochloride (propan-2-ol) hydrate

Target:

5-HT Receptor

Research Areas:

Neurological Disease Cancer

Flibanserin (BIMT-17) hydrochloride (propan-2-ol) hydrate is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K_i values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride (propan-2-ol) hydrate binds to dopamine D4 receptors with an K_i value of 4-24 nM. Flibanserin hydrochloride (propan-2-ol) hydrate shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research ^- .

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1

Melanotan I

1 Cited Publications

Cat. No.: HY-N2466

CAS No.: 75921-69-6

Synonyms: MT-I; [Nle4,D-Phe7]-α-MSH

Target:

Melanocortin Receptor Drug Derivative

Research Areas:

Metabolic Disease Inflammation/Immunology Endocrinology Cancer

Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction .

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1

Bremelanotide Acetate

1 Cited Publications

Cat. No.: HY-18678A

CAS No.: 1607799-13-2

Synonyms: PT-141 Acetate

Target:

Melanocortin Receptor

Research Areas:

Metabolic Disease

Bremelanotide (PT-141) Acetate is a melanocortin receptor agonist. Bremelanotide Acetate can activate MC4R and increases dopamine release. Bremelanotide Acetate induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide Acetate can be used for the research of hypoactive sexual desire disorders .

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1

Bremelanotide

1 Cited Publications

Cat. No.: HY-18678

CAS No.: 189691-06-3

Synonyms: PT-141

Target:

Melanocortin Receptor

Research Areas:

Neurological Disease Metabolic Disease

Bremelanotide (PT-141) is a melanocortin receptor agonist. Bremelanotide can activate MC4R and increases dopamine release. Bremelanotide induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide can be used for the research of hypoactive sexual desire disorders .

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1

Rosoxacin

1 Cited Publications

Cat. No.: HY-A0208

CAS No.: 40034-42-2

Synonyms: Acrosoxacin

Target:

Bacterial Antibiotic

Research Areas:

Infection

Rosoxacin (Acrosoxacin) is an orally active and broad-spectrum antibacterial quinolone antibiotic. Rosoxacin inhibits Gram-negative bacteria, including N. gonorrhoeae (MIC range=0.03-0.125 µg/mL).Rosoxacin can be used in studies of urinary tract infections and certain sexually transmitted diseases .

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1

FNDR-20123

1 Cited Publications

Cat. No.: HY-131708A

CAS No.: 2641930-61-0

Purity: 98.00%

Target:

HDAC Parasite

Research Areas:

Infection

FNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC₅₀s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC₅₀=41 nM) and sexual blood stage (IC₅₀=190 nM for male gametocytes). FNDR-20123 inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC₅₀=25/29/2/11/282 nM, respectively.) and inhibits Class III HDAC isoforms at nanomolar concentrations .

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1

Melanotan I acetate

1 Cited Publications

Cat. No.: HY-N2466A

CAS No.: 1566590-77-9

Synonyms: MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate

Target:

Melanocortin Receptor Drug Derivative

Research Areas:

Metabolic Disease Inflammation/Immunology Endocrinology Cancer

Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) acetate is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I acetate induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I acetate impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I acetate can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction .

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