11 Results for "

silico

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "silico" in MCE Product Catalog:

2
Cichoriin
Cichoriin
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2 Cited Publications
Cat. No.: HY-N8599
CAS No.: 531-58-8
Category:  

Infection Monophenols Coumarins Phenols Phenylpropanoids Plants Other Families Extract Disease Research Fields

Target:  

Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB

Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC50 values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y14R (IC50 = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .
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1
IDE-IN-2
IDE-IN-2
0 Images
1 Cited Publications
Cat. No.: HY-W157689
CAS No.: 49619-58-1
Target:  

Proteolytic Enzyme IDE

Research Areas:  

Infection Metabolic Disease Cancer

IDE-IN-2 (Compound 4) is an inhibitor for insulin-degrading enzyme. IDE-IN-2 is predicted to have CYP3A4, CYP2C19, hERG, NADP+, HIF1α and histidine kinase inhibitory activities, and has potential biological activity in anti-diabetic, anti-tumor, anti-bacterial aspects, according to the in silico prediction .
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Prunetrin
Prunetrin
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Cat. No.: HY-N7645
CAS No.: 154-36-9
Synonyms: Trifoside; Prunetin 4′-O-β-D-glucopyranoside
Category:  

Flavonoids Other Diseases Rosaceae Extract 500 - Internal Server Error | MedChemExpress

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