2 Results for "

splicing silencers

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "splicing silencers" in MCE Product Catalog:

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Cat. No.: HY-189604
CAS No.: 2927390-43-8
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

RNA splicing modulator 7 is an RNA splicing modulator. RNA splicing modulator 7 modulates mRNA splicing by targeting cis-elements of primary RNA transcripts (such as splice sites, branch points, splicing enhancers, or splicing silencers). RNA splicing modulator 7 has anticancer activity against leukemia .
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Cat. No.: HY-P11698
CAS No.: 476667-31-9
Research Areas:  

Cancer

Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as miR-155 or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis .
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