51

51 Publications Verification

Target:

Research Areas:

DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune reactions. Decreased DNase I activity may be associated with the occurrence and development of systemic lupus erythematosus (SLE). DNase I (filtered) is filtered through a 0.22 μM membrane and is not tested for pyrogenicity .

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27

3-Indoleacetic acid

27 Cited Publications

Cat. No.: HY-18569

CAS No.: 87-51-4

Synonyms: indole-3-acetic acid; 3-IAA

3-Indoleacetic acid is is an IAA hormone and growth regulator that can promote plant nutritional growth through processes such as cell expansion, differentiation, morphogenesis, and organogenesis .

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27

3-Indoleacetic acid sodium

27 Cited Publications

Cat. No.: HY-18569A

CAS No.: 6505-45-9

Synonyms: indole-3-acetic acid sodium; 3-IAA sodium

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

3-Indoleacetic acid sodium is is an IAA hormone and growth regulator that can promote plant nutritional growth through processes such as cell expansion, differentiation, morphogenesis, and organogenesis .

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21

Hyaluronidase, Ovine testes

21 Cited Publications

Cat. No.: HY-108903A

CAS No.: 37326-33-3

Purity: 95.00%

Target:

Glycosidase Biochemical Assay Reagents

Research Areas:

Endocrinology

Hyaluronidase, Ovine testes is an endoglycosidase. Hyaluronidase, Ovine testes specifically degrades Hyaluronic acid (HY-B0633A) and Chondroitin sulfate (HY-B2162) by hydrolyzing β-glycosidic bonds in acidic mucopolysaccharides. Hyaluronidase, Ovine testes disperses follicular cells during fertilization by breaking down the hyaluronic acid-rich cumulus. Hyaluronidase, Ovine testes can be used in the study of fertility-related diseases .

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21

Hyaluronidase, Bovine testes

21 Cited Publications

Cat. No.: HY-107910

CAS No.: 37326-33-3

Synonyms: Hyaluronate 4-glycanohydrolase, Bovine testes; Hyaluronoglucosaminidase, Bovine testes

Target:

NF-κB

Research Areas:

Inflammation/Immunology Cancer

Hyaluronidase, Bovine testes (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection .

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19

Indole-3-carbinol

19 Cited Publications

Cat. No.: HY-N0170

CAS No.: 700-06-1

Synonyms: indole-3-methanol

Category:

Alkaloids Plants Other Families Extract Endogenous metabolite Disease Research Fields Cancer Indole Alkaloids

Target:

NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite

Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

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17

Indolelactic acid

17 Cited Publications

Cat. No.: HY-113099

CAS No.: 1821-52-9

Purity: 99.99%

Synonyms: indole-3-lactic acid

Category:

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity .

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15

3-Indolepropionic acid

15 Cited Publications

Cat. No.: HY-W015229

CAS No.: 830-96-6

Synonyms: indole-3-propionic acid; 3-IPA

Category:

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite

Target:

Endogenous Metabolite Reactive Oxygen Species (ROS)

3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.

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14

Indirubin

14 Cited Publications

Cat. No.: HY-N0117

CAS No.: 479-41-4

Synonyms: Couroupitine B; Indigo red; Indigopurpurin

Category:

Alkaloids Plants Other Families Extract Disease Research Fields Cancer Indole Alkaloids

Target:

Apoptosis

Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .

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13

Sodium citrate dihydrate, meets USP testing specifications

13 Cited Publications

Cat. No.: HY-B1610E

CAS No.: 6132-04-3

Synonyms: Trisodium citrate dihydrate, meets USP testing specifications

Sodium citrate (Trisodium citrate) dihydrate, meets USP testing specifications is an orally active natural product that can be found in citrus fruits. Sodium citrate dihydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dihydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dihydrate can be prepared as a cosolvent or buffer .

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12

Paxilline

12 Cited Publications

Cat. No.: HY-N6778

CAS No.: 57186-25-1

Category:

Alkaloids Microorganisms Neurological Disease Terpenoids Diterpenoids Plants Other Families Extract Disease Research Fields Indole Alkaloids

Target:

Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)

Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

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11

Z-Gly-Gly-Arg-AMC

11 Cited Publications

Cat. No.: HY-P0019

CAS No.: 66216-78-2

Target:

Fluorescent Dye Thrombin

Research Areas:

Cardiovascular Disease

Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .

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11

Z-Gly-Gly-Arg-AMC acetate

11 Cited Publications

Cat. No.: HY-P0019A

CAS No.: 2070009-61-7

Target:

Fluorescent Dye Thrombin

Research Areas:

Others

Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .

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11

Pirtobrutinib

11 Cited Publications

Cat. No.: HY-131328

CAS No.: 2101700-15-4

Purity: 99.88%

Synonyms: LOXO-305

Target:

Btk

Research Areas:

Cancer

Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM .

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8

Crenigacestat

8 Cited Publications

Cat. No.: HY-12449

CAS No.: 1421438-81-4

Purity: 99.01%

Synonyms: LY3039478

Target:

Notch γ-secretase

Research Areas:

Cancer

Crenigacestat (LY3039478) is an orally active Notch and γ-secretase inhibitor, with an IC₅₀ of 1 nM in most of the tumor cell lines tested .

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8

AXKO-0046 dihydrochloride

8 Cited Publications

Cat. No.: HY-147216A

Purity: 99.68%

Target:

Lactate Dehydrogenase

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

AXKO-0046 dihydrochloride, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC₅₀ value of 42 nM. AXKO-0046 dihydrochloride can be used for the research of cancer metabolism .

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8

AXKO-0046

8 Cited Publications

Cat. No.: HY-147216

CAS No.: 3103525-82-9

Purity: 99.77%

Target:

Lactate Dehydrogenase

Research Areas:

Cancer

AXKO-0046, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor.AXKO-0046 has LDHB inhibitory activity with an EC₅₀ value of 42 nM.AXKO-0046 can be used for the research of cancer metabolism .

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8

Tryptanthrin

8 Cited Publications

Cat. No.: HY-N6607

CAS No.: 13220-57-0

Category:

Alkaloids Plants Disease Research Fields Inflammation/Immunology 500 - Internal Server Error | MedChemExpress

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