69 Results for "

stereoselectivity

" in MedChemExpress (MCE) Product Catalog:
Products (69)

69 Results for "stereoselectivity" in MCE Product Catalog:

5
20(S)-Hydroxycholesterol
20(S)-Hydroxycholesterol
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5 Cited Publications
Cat. No.: HY-12316
CAS No.: 516-72-3
Purity:  99.29%
Synonyms: 20α-Hydroxycholesterol
Category:  

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

Smo Endogenous Metabolite

20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .
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2
MY-1B
MY-1B
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2 Cited Publications
Cat. No.: HY-158301
CAS No.: 2929308-79-0
Purity:  99.94%
Target:  

DNA Methyltransferase Ligands for E3 Ligase RNA MTase

Research Areas:  

Cancer

MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes .
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2
L-365260
L-365260
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2 Cited Publications
Cat. No.: HY-106840
CAS No.: 118101-09-0
Purity:  99.93%
Target:  

Cholecystokinin Receptor

Research Areas:  

Neurological Disease Metabolic Disease

L-365260 is an orally active and selective antagonist of non-peptide gastrin and brain cholecystokinin receptor (CCK-B), with Kis of 1.9 nM and 2.0 nM, respectively. L-365260 interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brain CCK receptors. L-365260 can enhance Morphine analgesia and prevents Morphine tolerance .
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2
Salsolidine
Salsolidine
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2 Cited Publications
Cat. No.: HY-22385
CAS No.: 5784-74-7
Category:  

Alkaloids Animals Isoquinoline Alkaloids

Target:  

Monoamine Oxidase

Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.
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2
L-365260 hemihydrate
L-365260 hemihydrate
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2 Cited Publications
Cat. No.: HY-106840A
Purity:  99.75%
Target:  

Cholecystokinin Receptor

Research Areas:  

Neurological Disease Metabolic Disease

L-365260 hemihydrate is an orally active and selective antagonist of non-peptide gastrin and brain cholecystokinin receptor (CCK-B), with Kis of 1.9 nM and 2.0 nM, respectively. L-365260 hemihydrate interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brain CCK receptors .
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1
(±)-Naproxen
(±)-Naproxen
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1 Cited Publications
Cat. No.: HY-15029
CAS No.: 23981-80-8
Purity:  99.79%
Synonyms: (Rac)-Naproxen
Target:  

17β-HSD

Research Areas:  

Inflammation/Immunology Cancer

(±)-Naproxen ((Rac)-Naproxen) is the racemate of Naproxen (HY-15030), consisting of R- and S-enantiomers. (±)-Naproxen binds to AKR1C3, which preferentially recognizes the R-enantiomer from the racemic mixture. It is used for AKR1C3 stereoselective ligand recognition and studies on NSAID binding mechanisms .
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(R)-(+)-tert-Butylsulfinamide
(R)-(+)-tert-Butylsulfinamide
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Cat. No.: HY-40228
CAS No.: 196929-78-9
Synonyms: (R)-2-Methylpropane-2-sulfinamide
(R)-(+)-tert-Butylsulfinamide ((R)-2-Methylpropane-2-sulfinamide) is a chiral reagent commonly used in the asymmetric synthesis of compounds such as amines, amino acids, and amino alcohols. (R)-(+)-tert-Butylsulfinamide achieves stereoselective reactions by condensing with carbonyl groups to form sulfinyl imine intermediates, and after the reaction, this group can be removed under acidic conditions to obtain the target product .
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WX-02-23
WX-02-23
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Cat. No.: HY-168534
CAS No.: 2929223-35-6
Target:  

SF3B1 Apoptosis FOXA

Research Areas:  

Cancer

WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer .
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(R)-(+)-Warfarin
(R)-(+)-Warfarin
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Cat. No.: HY-W015998
CAS No.: 5543-58-8
(R)-(+)-Warfarin is an orally active chiral 4-hydroxycoumarin compound with vitamin K epoxide reductase (VKOR) inhibitory activity and cytochrome P450 substrate activity . (R)-(+)-Warfarin undergoes stereoselective metabolism via CYP1A2 to form 6-Hydroxywarfarin and 8-Hydroxywarfarin, and is metabolized via CYP3A4 to produce 10-Hydroxywarfarin (HY-134999). (R)-(+)-Warfarin can be used for the research of thromboembolic diseases .
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(R)-Reticuline
(R)-Reticuline
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Cat. No.: HY-N1356A
CAS No.: 3968-19-2
Category:  

Alkaloids Lauraceae Extract Plants Isoquinoline Alkaloids 500 - Internal Server Error | MedChemExpress

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