2 Results for "

steroid-binding site

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "steroid-binding site" in MCE Product Catalog:

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Lunularin
Lunularin
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Cat. No.: HY-124529
CAS No.: 37116-80-6
Category:  

Conocephalum conicum (L.) Dumort. Extract Human Gut Microbiota Metabolites Plant Phenols Polyphenols Other Families Extract Endogenous metabolite

Target:  

11β-HSD Endogenous Metabolite

Lunularin is an inhibitor of 11β-hydroxysteroid dehydrogenase 1, with an IC50 of 45.44 μM and a Ki of 35.8 μM against human 11β-HSD1, and an IC50 of 17.39 μM and a Ki of 10.31 μM against rat 11β-HSD1. Lunularin upregulates the transcription levels of Sirt1 and Hmox1 genes in the liver. Lunularin reduces food intake and body weight gain, and decreases blood glucose levels in mice fed a high-fat diet. Lunularin inhibits LPS-induced TLR4-mediated NF-κB pathway activation and nitric oxide production. Lunularin inhibits the proliferation and colony formation of renal cancer and colon cancer cells, and exhibits cancer cell-specific cytotoxicity. Lunularin binds to the steroid-binding site of human 11β-HSD1 and the steroid/NADPH-binding region of rat 11β-HSD1, but does not inhibit 11β-HSD2 or mouse 11β-HSD1. Lunularin can be used in research related to diet-induced obesity, renal cancer, colorectal cancer, inflammatory diseases and metabolic syndrome .
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Etaconazol
Etaconazol
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Cat. No.: HY-W714186
CAS No.: 60207-93-4
Synonyms: Etaconazole
Target:  

Bacterial Fungal

Research Areas:  

Infection

Etaconazol (Etaconazole) is an azole fungicide. Etaconazol possesses endocrine-disrupting potential and inhibits placental steroidogenesis by suppressing 3β-hydroxysteroid dehydrogenase (3β-HSD1). Etaconazol binds to the NAD +/steroid-binding site of the target enzyme and acts on both the free enzyme and enzyme-substrate complex to inhibit their activity .
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