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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
104 Results for "
stress-activated
" in MedChemExpress (MCE) Product Catalog:
Products (104)
104 Results for "stress-activated" in MCE Product Catalog:
4
Category:
4
4 Cited Publications
Target:
Research Areas:
SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research .
4
4 Cited Publications
Cat. No.: HY-P80728
Synonyms: JNK1; PRKM8; SAPK1; SAPK1C; MAPK8; Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; JNK-46; stress-activated protein kinase 1c; stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; SAPK1c
3
3 Cited Publications
Cat. No.: HY-P80996
Synonyms: CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A, MAPK14, Mitogen-activated protein kinase 14, MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, stress-activated protein kinase 2a, CSAID-binding protein, MAP kinase p38 alpha, SAPK2a
3
3 Cited Publications
Cat. No.: HY-P80842
Synonyms: CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; MAPK14; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; stress-activated protein kinase 2a; CSAID-binding protein; MAP kinase p38 alpha; SAPK2a
2
2 Cited Publications
Cat. No.: HY-P80776
Synonyms: CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; MAPK14; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; stress-activated protein kinase 2a; CSAID-binding protein; MAP kinase p38 alpha; SAPK2a
2
2 Cited Publications
Cat. No.: HY-P80777
Synonyms: CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; MAPK14; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; stress-activated protein kinase 2a; CSAID-binding protein; MAP kinase p38 alpha; SAPK2a
1
1 Cited Publications
Cat. No.: HY-W011109
CAS No.: 1177141-67-1
Target:
Research Areas:
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases .
1
1 Cited Publications
Cat. No.: HY-133028
CAS No.: 120615-25-0
Target:
Research Areas:
CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases .
1
1 Cited Publications
Cat. No.: HY-P73848
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK8; JNK-46; Prev. PRKM8; stress-activated Protein Kinase JNK1; SAPK1; stress-activated Protein Kinase JNK; JNK1; stress-activated Protein Kinase 1; JNK; JNK21B1/2; stress-activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Terminal Kinase; SAPK1C; MAP Kinase 8; Mitogen-activated Protein Kinase 8; SAPK1c
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P80213
Synonyms: CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A, MAPK14, Mitogen-activated protein kinase 14, MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, stress-activated protein kinase 2a, CSAID-binding protein, MAP kinase p38 alpha, SAPK2a
1
1 Cited Publications
Cat. No.: HY-P80776A
Synonyms: CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; MAPK14; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; stress-activated protein kinase 2a; CSAID-binding protein; MAP kinase p38 alpha; SAPK2a
Research Areas:
HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1). HKB99 induces apoptosis. HKB99 inhibits the formation of invasive pseudopodia and inhibits migration. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and ERK. HKB99 can be used for the research of non-small-cell lung cancer (NSCLC) .
Cat. No.: HY-B2035
CAS No.: 51218-49-6
Target:
Herbicide Environmental Pollutants Caspase Cytochrome P450 MDM-2/p53 Interleukin Related Reactive Oxygen Species (ROS) Apoptosis
Research Areas:
Pretilachlor is a chloroacetamide herbicide with biological activities including endocrine disruption, oxidative stress induction, apoptosis induction, and immunotoxicity. Pretilachlor exerts its effects by interfering with hormone metabolism, inducing oxidative stress, activating apoptotic pathways, and inhibiting immune functions. Pretilachlor upregulates the transcription of P53, Mdm2, and Bbc3, and increases the activities of Caspase3 and Caspase9; it upregulates the transcription of genes in the HPG/HPT axis and the activity of aromatase; it induces oxidative stress, elevates ROS levels, and upregulates CAT, SOD, and GPX. Pretilachlor downregulates the transcription of CXCL-C1C, IL-1β, and IL-8. Pretilachlor disrupts the normal physiological processes and embryonic development of fish, exhibiting significant toxicity. Pretilachlor can be used in studies related to weeding, environmental pollution, and behavioral toxicity in fish .
Cat. No.: HY-114038
CAS No.: 607372-46-3
Target:
Research Areas:
SB-747651A is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A can be used for inflammation research .
Synonyms: DHNQ (Standard); 5,8-Dihydroxy-1,4-naphthoquinone (Standard)
Category:
Quinones Plant Juglandaceae Extract Phenols Polyphenols Juglans sigillata Dode Extract Naphthalene Quinones
Target:
Cat. No.: HY-178940
Research Areas:
Apoptosis inducer 49 is a selective apoptosis inducer with high specificity against CCRF-CEM leukemia cells (IC50 = 2.68 μM). Apoptosis inducer 49 enhances RNA synthesis and replication stress, activates the Chk1-p21 axis, leading to S-phase arrest. Apoptosis inducer 49 can inhibit Bcl-2 and activate caspase-3. Apoptosis inducer 49 can be used for the study of Leukemia .
Cat. No.: HY-110313R
CAS No.: 1781882-72-1
Target:
Research Areas:
SB-747651A (dihydrochloride) (Standard) is the analytical standard of SB-747651A (dihydrochloride). This product is intended for research and analytical applications. SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research .
Cat. No.: HY-P703020
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK8; JNK-46; Prev. PRKM8; stress-activated Protein Kinase JNK1; SAPK1; stress-activated Protein Kinase JNK; JNK1; stress-activated Protein Kinase 1; JNK; JNK21B1/2; stress-activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P705577
Synonyms: MAPK8; JNK-46; Prev. PRKM8; stress-activated Protein Kinase JNK1; SAPK1; stress-activated Protein Kinase JNK; JNK1; stress-activated Protein Kinase 1; JNK; JNK21B1/2; stress-activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
