948 Results for "

sulfate esterification

" in MedChemExpress (MCE) Product Catalog:

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226

Bleomycin sulfate

226 Cited Publications

Cat. No.: HY-17565

CAS No.: 9041-93-4

Synonyms: Bleomycin sulfate

Category:

Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer

Target:

DNA/RNA Synthesis Antibiotic

Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic .

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154

Erlotinib Hydrochloride

154 Cited Publications

Cat. No.: HY-12008

CAS No.: 183319-69-9

Purity: 99.94%

Synonyms: CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride

Target:

EGFR OAT ERK GSK-3 β-catenin

Research Areas:

Endocrinology Cancer

Erlotinib (CP-358774) Hydrochloride is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib Hydrochloride also acts as a substrate and inhibitor of OATP2B1, with an IC₅₀ of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib Hydrochloride blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib Hydrochloride inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, as well as the deposition of fibronectin, α-SMA, collagen and renal injury markers. Erlotinib Hydrochloride is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib Hydrochloride can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, EGFR inhibitor resistance and renal fibrosis .

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154

Erlotinib

154 Cited Publications

Cat. No.: HY-50896

CAS No.: 183321-74-6

Synonyms: CP-358774; NSC 718781; OSI-774

Target:

EGFR OAT ERK GSK-3 β-catenin

Research Areas:

Endocrinology Cancer

Erlotinib (CP-358774) is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib also acts as a substrate and inhibitor of OATP2B1, with an IC₅₀ of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, fibronectin, α-SMA, collagen deposition, and renal injury markers. Erlotinib is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, pancreatic cancer, renal fibrosis, and other conditions .

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103

Selumetinib sulfate

103 Cited Publications

Cat. No.: HY-50706A

CAS No.: 943332-08-9

Synonyms: AZD6244 sulfate; ARRY-142886 sulfate

Target:

MEK Apoptosis

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Selumetinib (AZD6244) sulfate is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC₅₀ of 14 nM for MEK1. Selumetinib (AZD6244) sulfate inhibits ERK1/2 phosphorylation. Selumetinib sulfate can penetrate the blood brain barrier (BBB) .

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Hydroxychloroquine sulfate

99 Cited Publications

Cat. No.: HY-B1370

CAS No.: 747-36-4

Synonyms: HCQ sulfate

Target:

Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy

Research Areas:

Infection Cancer

Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro .

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Vincristine sulfate

85 Cited Publications

Cat. No.: HY-N0488

CAS No.: 2068-78-2

Synonyms: Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate

Category:

Alkaloids Anti-aging Plants Disease Research Fields Cancer Alkaloid Dimers Apocynaceae Extract 500 - Internal Server Error | MedChemExpress

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