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142 Results for "

syk

" in MedChemExpress (MCE) Product Catalog:

Products (142)

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R406

40 Publications Verification

Cat. No.: HY-12067

CAS No.: 841290-81-1

Purity: 96.70%

Target:

Syk FLT3 Apoptosis

Research Areas:

Inflammation/Immunology Cancer

R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a K_i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC₅₀ of 41 nM, measured at an ATP concentration corresponding to its K_m value. R406 reduces immune complex-mediated inflammation . R406 also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

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R406 free base

40 Publications Verification

Cat. No.: HY-11108

CAS No.: 841290-80-0

Purity: 99.80%

Target:

Syk FLT3 Apoptosis

Research Areas:

Inflammation/Immunology Cancer

R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a K_i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC₅₀ of 41 nM, measured at an ATP concentration corresponding to its K_m value. R406 free base reduces immune complex-mediated inflammation . R406 free base also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

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Midostaurin

40 Publications Verification

Cat. No.: HY-10230

CAS No.: 120685-11-2

Purity: 99.91%

Synonyms: PKC412; CGP 41251

Target:

PKC VEGFR c-Kit NO Synthase Apoptosis

Research Areas:

Cancer

Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

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