468

Puromycin

468 Publications Verification

Cat. No.: HY-B1743

CAS No.: 53-79-2

Synonyms: CL13900

Category:

Infection Alkaloids Microorganisms Other Alkaloids Disease Research Fields

Target:

Bacterial Antibiotic Parasite

Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

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468

Puromycin dihydrochloride

468 Publications Verification

Cat. No.: HY-B1743A

CAS No.: 58-58-2

Synonyms: CL13900 dihydrochloride

Category:

Infection Microorganisms Antibiotics Resistance Selection Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:

Bacterial Antibiotic Parasite

Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis .

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365

5-Fluorouracil

365 Cited Publications

Cat. No.: HY-90006

CAS No.: 51-21-8

Synonyms: 5-FU

Category:

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

Exosomes Nucleoside Antimetabolite/Analog HIV Apoptosis Endogenous Metabolite

5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .

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307

Gemcitabine hydrochloride

307 Cited Publications

Cat. No.: HY-B0003

CAS No.: 122111-03-9

Synonyms: LY 188011 hydrochloride

Target:

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Autophagy Apoptosis

Research Areas:

Cancer

Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .

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245

Oxaliplatin

245 Cited Publications

Cat. No.: HY-17371

CAS No.: 61825-94-3

Target:

DNA/RNA Synthesis Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research .

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243

Pevonedistat hydrochloride

243 Cited Publications

Cat. No.: HY-10484

CAS No.: 1160295-21-5

Purity: 98.58%

Synonyms: MLN4924 hydrochloride

Target:

NEDD8-activating Enzyme Apoptosis

Research Areas:

Cancer

Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC₅₀ of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice .

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230

Remdesivir

230 Cited Publications

Cat. No.: HY-104077

CAS No.: 1809249-37-3

Purity: 99.95%

Synonyms: GS-5734

Target:

DNA/RNA Synthesis SARS-CoV

Research Areas:

Infection

Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .

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226

Bleomycin hydrochloride

226 Cited Publications

Cat. No.: HY-17565A

CAS No.: 67763-87-5

Target:

DNA/RNA Synthesis Antibiotic

Research Areas:

Cancer

Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic .

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226

Bleomycin sulfate

226 Cited Publications

Cat. No.: HY-17565

CAS No.: 9041-93-4

Synonyms: Bleomycin sulfate

Category:

Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer

Target:

DNA/RNA Synthesis Antibiotic

Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic .

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172

ATP disodium salt, 100 mM Solution, PCR Grade

172 Cited Publications

Cat. No.: HY-B2176I

CAS No.: 987-65-5

Synonyms: Adenosine 5'-triphosphate disodium salt, 100 mM Solution, PCR Grade

ATP (Adenosine 5'-triphosphate) disodium salt, 100 mM Solution, PCR Grade is a central component of energy storage and metabolism in vivo. ATP disodium salt, 100 mM Solution, PCR Grade provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt, 100 mM Solution, PCR Grade is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt, 100 mM Solution, PCR Grade can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt, 100 mM Solution, PCR Grade has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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166

Anisomycin

166 Cited Publications

Cat. No.: HY-18982

CAS No.: 22862-76-6

Synonyms: Flagecidin; Wuningmeisu C

Category:

Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:

DNA/RNA Synthesis JNK Bacterial Apoptosis Antibiotic Parasite

Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system . Anisomycin is a JNK activator, which increases phospho-JNK . Anisomycin is a bacterial antibiotic .

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121

Fludarabine

121 Cited Publications

Cat. No.: HY-B0069

CAS No.: 21679-14-1

Synonyms: F-ara-A; NSC 118218

Target:

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis STAT Apoptosis

Research Areas:

Cancer

Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes .

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112

Vancomycin hydrochloride

112 Cited Publications

Cat. No.: HY-17362

CAS No.: 1404-93-9

Category:

Disease Research Antibacterial Other Antibiotics Microorganisms Plant Cell Culture Antibiotics Phenols Polyphenols Disease Research Fields Cancer

Target:

Bacterial Autophagy Antibiotic

Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.

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111

Cytarabine hydrochloride

111 Cited Publications

Cat. No.: HY-13605A

CAS No.: 69-74-9

Purity: 99.67%

Synonyms: Cytosine β-D-arabinofuranoside hydrochloride; Cytosine Arabinoside hydrochloride; Ara-C hydrochloride

Target:

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy

Research Areas:

Infection Cancer

Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.

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111

Cytarabine

111 Cited Publications

Cat. No.: HY-13605

CAS No.: 147-94-4

Purity: 99.98%

Synonyms: Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C

Category:

Infection Natural Products Microorganisms Marine natural products Sponge Endogenous metabolite Disease Research Fields

Target:

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus

Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

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101

Carboplatin

101 Cited Publications

Cat. No.: HY-17393

CAS No.: 41575-94-4

Synonyms: NSC 241240

Target:

DNA Alkylator/Crosslinker Autophagy DNA/RNA Synthesis

Research Areas:

Cancer

Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.

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83

Puromycin, Sterile

83 Cited Publications

Cat. No.: HY-K1057

Puromycin is an aminonucleoside antibiotic produced by Streptomyces alboniger. It inhibits protein synthesis by disrupting peptide transfer on ribosomes, causing premature chain termination during translation. It can kill most gram-positive bacteria and various animal or insect cells.

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