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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
synucleinopathies
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "synucleinopathies" in MCE Product Catalog:
Synonyms: ASN90
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Egalognastat (ASN90) is a selective, brain-penetrant and orally active O-GlcNAcase (OGA) enzyme inhibitor with an IC50 value of 10.2 nM. Egalognastat increases O-GlcNAcylation of intracellular proteins like tau and α-synuclein, preventing their aggregation and toxicity. Egalognastat does not inhibit hexosaminidase (Hex). Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies (e.g., Alzheimer’s disease and Parkinson’s disease) .
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PROTAC α-synuclein degrader 5 is a selective PROTAC degrader targeting α‑synuclein aggregates, with a DC50 of 7.51 μM. PROTAC α-synuclein degrader 5 binds to αSyn aggregates, recruits the CRBN E3 ubiquitin ligase, and mediates the ubiquitination and subsequent degradation of α‑synuclein aggregates. PROTAC α-synuclein degrader 5 activates the autophagy-lysosome pathway. PROTAC α-synuclein degrader 5 reduces ROS levels in neuroblastoma cells, restores mitochondrial membrane potential, rescues cell viability, and decreases LDH release. PROTAC α-synuclein degrader 5 degrades αSyn aggregates in Caenorhabditis elegans and ameliorates oxidative stress. PROTAC α-synuclein degrader 5 is used for the research of synucleinopathies, such as Parkinson's disease .
Cat. No.: HY-170035
CAS No.: 95119-86-1
Synonyms: C18 Glucosyl(β) ceramide (d18:1/18:0); D-glucosyl-β-1,1' N-stearoyl-D-erythro-sphingosine
GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a glycosphingolipids that activates the Wnt/β-catenin pathway by targeting LRP6. GlcCer (d18:1/18:0) drives EMT, migration, invasion and GBA1-mediated liver cancer metastasis. GlcCer (d18:1/18:0) accumulates to impair lysosomal function and induce toxic α-synuclein aggregation. GlcCer (d18:1/18:0) supports growth, sporulation, germination and virulence in Penicillium digitatum. GlcCer (d18:1/18:0) is reduced in demyelinated mouse corpus callosum. GlcCer (d18:1/18:0) can be used for the research of liver cancer, synucleinopathies, fungal, Parkinson’s disease and Gaucher disease .
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YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC50s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies .
Cat. No.: HY-177647
CAS No.: 2411937-33-0
Synonyms: BIIB-101; ION-464
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Movronersen (BIIB-101; ION-464) is an antisense oligonucleotide that targets SNCA; it promotes the degradation of SNCA mRNA and downregulates the synthesis of α-synuclein. By reducing the production of α-synuclein, Movronersen decreases protein misfolding and aggregation, thereby interfering with the pathological progression of synucleinopathies. Movronersen is used in research related to multiple system atrophy and associated disorders .
Cat. No.: HY-177647A
Synonyms: BIIB-101 sodium; ION-464 sodium
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Movronersen sodium (BIIB-101 sodium; ION-464 sodium) is an antisense oligonucleotide that targets SNCA; it promotes the degradation of SNCA mRNA and downregulates the synthesis of α-synuclein. By reducing the production of α-synuclein, Movronersen sodium decreases protein misfolding and aggregation, thereby interfering with the pathological progression of synucleinopathies. Movronersen sodium is used in research related to multiple system atrophy and associated disorders .
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WAY-309236 is an active molecule for the study of amyloid diseases and synucleinopathies.
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WAY-311474 is an active molecule for research into amyloid diseases and synucleinopathies.
Cat. No.: HY-47596
CAS No.: 300809-10-3
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WAY-612453 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-47599
CAS No.: 643042-43-7
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WAY-639418 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-47600
CAS No.: 854135-42-5
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WAY-323756 is an active molecule for research into amyloid diseases and synucleinopathies.
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WAY-622252 is an active molecule for the study of amyloid diseases and synucleinopathies.
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WAY-385995 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-49458
CAS No.: 149045-58-9
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WAY-232897 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-49460
CAS No.: 796059-20-6
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WAY-639299 is an active molecule for research into amyloid diseases and synucleinopathies.
Cat. No.: HY-49601
CAS No.: 957511-97-6
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WAY-329738 is an active molecule for research into amyloid diseases and synucleinopathies.
Cat. No.: HY-W436420
CAS No.: 1005086-69-0
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WAY-299375 is an active molecule for research into amyloid diseases and synucleinopathies.
Cat. No.: HY-W674257
CAS No.: 42310-54-3
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WAY-658674 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-W674612
CAS No.: 404360-27-6
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WAY-297848 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-W674624
CAS No.: 620570-09-4
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WAY-312858 is an active molecule for the study of amyloid diseases and synucleinopathies.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
