271

Protease Inhibitor Cocktail, mini-Tablet (EDTA-Free)

271 Publications Verification

MCE Protease Inhibitor Cocktail, mini-Tablet (EDTA-Free) is a blend of 5 pan-protease inhibitors for protection of protein integrity. The 25 pcs is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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38

C188-9

38 Cited Publications

Cat. No.: HY-112288

CAS No.: 432001-19-9

Purity: 99.90%

Synonyms: TTI-101

Target:

STAT Apoptosis DNA Methyltransferase

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

C188-9 (TTI-101) is a STAT3 inhibitor with a K_d value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia .

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7

LAP

7 Cited Publications

Cat. No.: HY-44076

CAS No.: 85073-19-4

Synonyms: Lithium phenyl-2,4,6-trimethylbenzoylphosphinate

LAP (Lithium phenyl-2,4,6-trimethylbenzoylphosphinate) is a free radical initiator. The free radicals produced by LAP under bioprinting conditions are potentially cytotoxic and mutagenic. In addition, the concentration of LAP affects the mechanical strength of 3D printed scaffolds. Generally, the concentration range of LAP used for curing is 0.05%-1%. The elastic modulus produced at a concentration of 0.1% is the highest, with enhanced mechanical properties and excellent biocompatibility .

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7

GLPG0492

7 Cited Publications

Cat. No.: HY-18102

CAS No.: 1215085-92-9

Target:

Androgen Receptor

Research Areas:

Neurological Disease

GLPG0492 is an orally active, non-steroidal selective androgen receptor modulator. GLPG0492 exerts functional transactivation by binding to the ligand-binding domain of the receptor, exhibiting preferential partial agonist activity in muscle and bone tissues with low activity in reproductive tissues. GLPG0492 effectively counteracts muscle atrophy-related pathways, significantly enhances muscle strength, maintains motor ability, reduces fibrosis and improves electrophysiological parameters. GLPG0492 prevents immobilization-induced muscle atrophy and regulates muscle mass homeostasis, serving as a valuable tool compound for studies on Duchenne muscular dystrophy, muscle loss and various types of disuse musculoskeletal atrophy .

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6

Clenbuterol hydrochloride

6 Cited Publications

Cat. No.: HY-B1614

CAS No.: 21898-19-1

Synonyms: NAB-365 hydrochloride

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Endocrinology

Target:

Adrenergic Receptor

Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage .

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5

UCL-TRO-1938

5 Cited Publications

Cat. No.: HY-154848

CAS No.: 2919575-27-0

Purity: 99.98%

Target:

PI3K Akt

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

UCL-TRO-1938 is a potent small molecule allosteric activator of PI3Kα with an EC₅₀ value of approximately 60 μM. UCL-TRO-1938 can induce cell proliferation and has cardioprotective effects from ischaemia reperfusion injury and enhances nerve regeneration following nerve crush .

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4

CHAPS

4 Cited Publications

Cat. No.: HY-15435

CAS No.: 75621-03-3

Purity: 99.91%

Target:

Exosomes Biochemical Assay Reagents

Research Areas:

Others

CHAPS is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm-Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS is commonly used in research on the separation and purification of membrane proteins .

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4

CHAPS hydrate

4 Cited Publications

Cat. No.: HY-15435A

CAS No.: 331717-45-4

Purity: ≥98.0%

CHAPS hydrate is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS hydrate exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS hydrate stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm‑Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS hydrate is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS hydrate cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS hydrate is commonly used in research on the separation and purification of membrane proteins .

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2

Tulobuterol

2 Cited Publications

Cat. No.: HY-B1810

CAS No.: 41570-61-0

Synonyms: C-78 free base

Target:

Adrenergic Receptor

Research Areas:

Inflammation/Immunology Endocrinology

Tulobuterol (C-78 free base) is a long-acting β₂-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength .

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2

Tulobuterol hydrochloride

2 Cited Publications

Cat. No.: HY-W011733

CAS No.: 56776-01-3

Synonyms: C-78

Target:

Adrenergic Receptor Influenza Virus Antibiotic

Research Areas:

Infection Inflammation/Immunology Endocrinology

Tulobuterol hydrochloride (C-78) is a long-acting β₂-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol hydrochloride is also a sympathomimetic agent used as a transdermal patch, increases normal diaphragm muscle strength . Tulobuterol hydrochloride inhibit rhinovirus replication and modulate airway inflammation .

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2

OVA-T4 Peptide

2 Cited Publications

Cat. No.: HY-P5411

CAS No.: 148274-88-8

Synonyms: SIITFEKL, OVA (257-264) Variant

Target:

MHC

Research Areas:

Cancer

OVA-T4 Peptide (SIITFEKL; OVA (257-264) Variant) is a modified peptide ligand of OVA 257-264 that binds to mouse OT-I TCR with K_d = 1.22 μM, acts as a weaker agonist than the parental N4 peptide to modulate the strength of antigen-presenting cell-T lymphocyte interactions, and alters the amplitude of cytokine responses and NFAT1, p-Erk, and NF-κB signaling responses. OVA-T4 Peptide can be used for research on colon cancer and ovarian cancer .

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1

Landogrozumab

1 Cited Publications

Cat. No.: HY-P99370

CAS No.: 1391726-30-9

Synonyms: LY2495655; Anti-GDF8 / Myostatin Reference Antibody (landogrozumab)

Landogrozumab (LY2495655) is an humanized anti-myostatin monoclonal antibody. Landogrozumab effectively improves muscle volume, hand grip strength and function. Landogrozumab can be used for the research of muscle wasting disease .

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1

Cross-linked dextran G 25

1 Cited Publications

Cat. No.: HY-148140

CAS No.: 9041-35-4

Target:

Biochemical Assay Reagents

Research Areas:

Others

Cross-linked dextran G 25 is a cross-linked dextran gel chromatography medium that possesses multiple separation activities, including molecular sieve effects, weak anion exchange, and aromatic adsorption. Cross-linked dextran G 25 weakly exchanges cations through immobilized terminal carboxyl groups and repels anions at low ionic strength. Cross-linked dextran G 25 is used for the fractionation of low molecular weight solutes, including peptides, amino acids, nucleotide sugar derivatives, and aromatic compounds .

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1

Multifungin

1 Cited Publications

Cat. No.: HY-B2140

CAS No.: 3679-64-9

Synonyms: Bromosalicylchloranilide; Salifungin

Target:

Fungal Bacterial

Research Areas:

Infection

Multifungin (Bromochlorosalicylanilide) is an antifungal that treats oral candidiasis . Multifungin prevents the formation and accumulation of Zearalenone and reduces the fungal population in stored-crushed corn .

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1

DN-1289

1 Cited Publications

Cat. No.: HY-152142

CAS No.: 3026597-15-6

Purity: 99.63%

Target:

JNK

Research Areas:

Neurological Disease

DN-1289 is an orally active and selective inhibitor of dual leucine zipper kinase (DLK; IC₅₀=17 nM) and leucine zipper-bearing kinase (LZK; IC₅₀=40 nM). DN-1289 results significant attenuation of optic nerve crush (ONC)-induced p-c-Jun in mice model. DN-1289 has excellent in vivo plasma half-life and blood-brain barrier permeability .

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1

Wilforine

1 Cited Publications

Cat. No.: HY-N0899

CAS No.: 11088-09-8

Category:

Cardiovascular Disease Celastraceae Extract Terpenoids Sesquiterpenes Plants 500 - Internal Server Error | MedChemExpress

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