6

Hydroxyprogesterone caproate

6 Publications Verification

Cat. No.: HY-B0742

CAS No.: 630-56-8

Synonyms: 17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate

Target:

Progesterone Receptor

Research Areas:

Endocrinology

Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Concanavalin A

5 Cited Publications

Cat. No.: HY-P2149

CAS No.: 11028-71-0

Concanavalin A can be coupled to agarose to form Concanavalin A (agarose) (HY-P2149A). Concanavalin A (ConA) is a selective, competitive binding agent that targets specific carbohydrate structures containing glucose and mannose; it acts as a mitogen and exhibits varying degrees of cytotoxicity, hepatotoxicity, and teratogenicity. Concanavalin A is also utilized for in vivo blood glucose monitoring in the context of diabetes .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Monobutyl phthalate

5 Cited Publications

Cat. No.: HY-N7143

CAS No.: 131-70-4

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Drug Metabolite

Monobutyl phthalate is an orally active metabolite of Di-n-butyl phthalate (HY-Y0304) and an embryotoxic agent. Monobutyl phthalate regulates mesodermal lineage gene expression, inhibits uterine decidualization, reduces fetal testosterone levels without directly binding to the androgen receptor, and induces teratogenic effects during organogenesis. Monobutyl phthalate induces testicular oxidative stress and sperm abnormalities. Monobutyl phthalate can be used in studies of developmental toxicity and male reproductive toxicity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

Patulin

4 Cited Publications

Cat. No.: HY-N6779

CAS No.: 149-29-1

Synonyms: Terinin

Category:

Infection Natural Products Microorganisms Disease Research Fields

Target:

Bacterial Apoptosis Autophagy Antibiotic

Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Hycanthone

2 Cited Publications

Cat. No.: HY-B1099

CAS No.: 3105-97-3

Target:

DNA/RNA Synthesis DNA Alkylator/Crosslinker Parasite IFNAR

Hycanthone is an apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor, DNA intercalator and Antischistosomal agent, with an IC₅₀ of 80 nM against APE1. Hycanthone irreversibly inhibits thymidine incorporation into DNA in adult sensitive *Schistosoma mansoni*, while exerts weak inhibitory effects on uridine and leucine incorporation. Hycanthone reduces influenza virus-induced interferon production. Hycanthone exhibits mutagenic effects in various organisms, shows teratogenicity in mice and rabbits, and induces neoplastic liver lesions in partially hepatectomized mice. Hycanthone can be used in research related to schistosomiasis and cancer .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

N-Methylpyrrolidone

1 Cited Publications

Cat. No.: HY-Y1275

CAS No.: 872-50-4

Synonyms: NMP; 1-Methyl-2-pyrrolidinone

Target:

Biochemical Assay Reagents

Research Areas:

Cancer

N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD₅₀ value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

L-Azetidine-2-carboxylic acid

1 Cited Publications

Cat. No.: HY-W050044

CAS No.: 2133-34-8

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite PERK Atg8/LC3 Autophagy Bcl-2 Family Apoptosis Eukaryotic Initiation Factor (eIF) ATF6

L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated eIF2α levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects .

Compare

loading...