243

Pevonedistat hydrochloride

243 Publications Verification

Cat. No.: HY-10484

CAS No.: 1160295-21-5

Purity: 98.58%

Synonyms: MLN4924 hydrochloride

Target:

NEDD8-activating Enzyme Apoptosis

Research Areas:

Cancer

Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC₅₀ of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice .

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243

Pevonedistat

243 Publications Verification

Cat. No.: HY-70062

CAS No.: 905579-51-3

Synonyms: MLN4924

Target:

NEDD8-activating Enzyme Apoptosis

Research Areas:

Cancer

Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC₅₀ of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice .

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52

DL-Dithiothreitol

52 Cited Publications

Cat. No.: HY-15917

CAS No.: 3483-12-3

Synonyms: DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol

DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .

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28

Filipin III

28 Cited Publications

Cat. No.: HY-N6718

CAS No.: 480-49-9

Category:

Microorganisms Antifungal Antibiotics Disease Research Disease Research Fields Inflammation/Immunology Other Antibiotics

Target:

Antibiotic Fungal

Filipin III is the major component of Filipin, a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure .

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23

Uridine

23 Cited Publications

Cat. No.: HY-B1449

CAS No.: 58-96-8

Synonyms: β-Uridine

Category:

Human Gut Microbiota Metabolites Natural Products Microorganisms Other Diseases Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Nucleoside Antimetabolite/Analog NF-κB

Uridine (β-Uridine) is a nucleoside compound composed of uracil and a ribose ring, which are connected by a β-N1-glycosidic bond .

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14

L-Cysteine hydrochloride

14 Cited Publications

Cat. No.: HY-Y0337A

CAS No.: 52-89-1

Category:

Anti-aging Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) .

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12

Guanosine

12 Cited Publications

Cat. No.: HY-N0097

CAS No.: 118-00-3

Synonyms: DL-Guanosine; Vernine

Category:

Natural Products Anti-aging Endocrine diseases Endogenous metabolite Infection Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Disease markers Disease Research Fields

Target:

HSV Endogenous Metabolite

Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.

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