7

RNase A, Bovine pancreas

7 Publications Verification

Cat. No.: HY-129046

CAS No.: 9001-99-4

Synonyms: Ribonuclease A; EC 4.6.1.18; RNase A

Target:

Endonuclease DNA/RNA Synthesis

Research Areas:

Others

RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability .

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2

ZY-444

2 Cited Publications

Cat. No.: HY-142870

CAS No.: 1802650-31-2

Purity: 98.70%

Target:

Pyruvate Carboxylase (PC) Apoptosis β-catenin ERK Wnt

Research Areas:

Cancer

ZY-444 is an anti-cancer agent, targeting pyruvate carboxylase (PC). ZY-444 suppresses the Wnt/β-catenin/Snail signaling pathway by blocking nuclear translocation of β-catenin. ZY-444 selectively inhibits proliferation, migration, and invasion and induces apoptosis in cancer cells. ZY-444 exhibits potent anti-tumor in cancer mouse models. ZY-444 can be used for the study of breast cancer, lung cancer (NSCLC), prostate cancer and iodine-refractory thyroid cancer .

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1

Tetrac

1 Cited Publications

Cat. No.: HY-W008859

CAS No.: 67-30-1

Synonyms: Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid

Category:

Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Cancer

Target:

Integrin Endogenous Metabolite

Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities .

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1

Fluopyram

1 Cited Publications

Cat. No.: HY-119459

CAS No.: 658066-35-4

Purity: 99.30%

Target:

Environmental Pollutants Constitutive Androstane Receptor Parasite Caspase Fungal NF-κB Succinate Dehydrogenase Pregnane X Receptor (PXR)

Research Areas:

Infection Cancer

Fluopyram is an orally active succinate dehydrogenase inhibitor, antifungal and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates CAR/PXR nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC₅₀ values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic .

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1

Icrucumab

1 Cited Publications

Cat. No.: HY-P99364

CAS No.: 1024603-92-6

Synonyms: Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1

Icrucumab (Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1) is an IgG1 antibody inhibitor targeting VEGFR-1/FLT1 with anti-tumor activity. By blocking ligand-dependent phosphorylation and downstream signal transduction, Icrucumab reduces the activities of MAPK and Akt in breast cancer xenograft models, inhibits the proliferation and invasion of VEGFR-1-positive tumor cells, and reverses the conversion of M1 macrophages to the pro-tumor M2-like phenotype. Icrucumab also inhibits tumor cell proliferation, promotes apoptosis, and effectively suppresses tumor growth through direct targeting of tumors and host support mechanisms. In addition, Icrucumab exhibits a synergistic effect when combined with chemotherapeutic agents, and it is used in research related to various cancers including advanced solid malignancies, thyroid cancer, melanoma, and lung cancer .

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1

RNase A, Recombinant

1 Cited Publications

Cat. No.: HY-129046D

CAS No.: 9001-99-4

Synonyms: Ribonuclease A, Recombinant

Target:

Endonuclease DNA/RNA Synthesis

Research Areas:

Endocrinology Cancer

RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability. RNase A, Recombinant (Ribonuclease A, Recombinant) is a recombinant form of RNase A .

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