26

26 Publications Verification

Target:

Research Areas:

Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation .

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23

Nimodipine

23 Cited Publications

Cat. No.: HY-B0265

CAS No.: 66085-59-4

Synonyms: BAY-e 9736

Target:

Autophagy Calcium Channel

Research Areas:

Cardiovascular Disease Cancer

Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders .

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18

Prazosin hydrochloride

18 Cited Publications

Cat. No.: HY-B0193A

CAS No.: 19237-84-4

Target:

Adrenergic Receptor Autophagy

Research Areas:

Cardiovascular Disease Endocrinology Cancer

Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders . Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC₅₀ of 0.15 nM .Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC₅₀s of 1.8, and 13 μM, respectively .

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12

Zotatifin

12 Cited Publications

Cat. No.: HY-112163

CAS No.: 2098191-53-6

Purity: 99.69%

Synonyms: eFT226

Target:

Eukaryotic Initiation Factor (eIF) SARS-CoV Apoptosis

Research Areas:

Infection Cancer

Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC₅₀=2 nM) and interferes with the assembly of the eIF4F initiation complex . Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC₉₀=37 nM) . Zotatifin induces cell apoptosis .

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8

Linrodostat

8 Cited Publications

Cat. No.: HY-101560

CAS No.: 1923833-60-6

Purity: 99.81%

Synonyms: BMS-986205; ONO-7701

Target:

Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Cancer

Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ value of 1.1 nM in IDO1-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers .

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7

Vanzacaftor

7 Cited Publications

Cat. No.: HY-145603

CAS No.: 2374124-49-7

Purity: 98.19%

Synonyms: VX-121

Target:

CFTR Chloride Channel

Research Areas:

Neurological Disease

Vanzacaftor (VX-121) is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of CFTR protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and CFTR function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases .

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