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8 Results for "

transcriptomes

" in MedChemExpress (MCE) Product Catalog:

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N-Propargylglycine

2 Cited Publications

Cat. No.: HY-142035

CAS No.: 58160-95-5

Purity: 99.70%

Target:

Mitochondrial Metabolism

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

N-Propargylglycine is a brain-penetrant and orally active PRODH inhibitor. N-Propargylglycine covalently modifies enzyme-bound FAD and active site lysine, causing enzyme structural distortion, protein decay, and irreversible inhibition of proline and 4-hydroxyproline catabolism. N-Propargylglycine induces UPRmt, upregulates mitochondrial chaperones and YME1L1, enhances mitochondrial proteostasis, blocks astrocytic L-proline consumption, and abolishes L-proline’s ATP-maintaining and viability-protective effects. N-Propargylglycine stimulates neural processes, increases brain proline, hydroxyproline, and sarcosine levels, partially normalizes Huntington’s disease whole brain transcriptomes. N-Propargylglycine reduces hyperoxaluria, prevents calcium oxalate stone formation, reduces kidney tubular damage, and restores weight and survival in Grhpr knockout mice. N-Propargylglycine can be used for the research of breast cancer, neurodegenerative disorders, Huntington’s disease, and primary hyperoxaluria type 2 .

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Linalool-d3

1 Cited Publications

Cat. No.: HY-N0368S

CAS No.: 1216673-02-7

Linalool-d₃ is the deuterium labeled Linalool . Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity .Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome .

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Biotin-aniline

Cat. No.: HY-139912

CAS No.: 769933-15-5

Purity: 99.63%

Target:

DNA Stain Biochemical Assay Reagents

Research Areas:

Others

Biotin-aniline is a probe with substantially high reactivity towards RNA and DNA. Biotin-aniline is also a novel APEX2 substrate. Biotin-aniline can label proteins via miniSOG. Biotin-aniline emerges as more efficient probe for capturing subcellular transcriptome in living cells with high spatial specificity .

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BAY1238097

Cat. No.: HY-112316

CAS No.: 1564268-08-1

Purity: 99.02%

Target:

Epigenetic Reader Domain

Research Areas:

Cancer

BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome (IC₅₀ <100 nM).

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