13

13 Publications Verification

Purity: ≥98.0%

Category:

Cardiovascular Disease Natural Products Microorganisms Other disease Disease markers Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:

Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite

Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

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13

Trimethylamine N-oxide dihydrate

13 Publications Verification

Cat. No.: HY-108915

CAS No.: 62637-93-8

Purity: ≥98.0%

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite

Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

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2

3,3-Dimethyl-1-butanol

2 Cited Publications

Cat. No.: HY-W012977

CAS No.: 624-95-3

Synonyms: DMB; Neohexanol

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NF-κB TGF-beta/Smad

3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and TGF-β1/Smad3. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD) .

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2

Glutathione ethyl ester

2 Cited Publications

Cat. No.: HY-134124

CAS No.: 92614-59-0

Purity: 95.8%

Target:

Reactive Oxygen Species (ROS)

Research Areas:

Metabolic Disease

Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

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2

delta-Valerobetaine

2 Cited Publications

Cat. No.: HY-114202

CAS No.: 6778-33-2

Purity: ≥98.0%

Category:

Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

delta-Valerobetaine is a precursor of trimethylamine N-oxide (TMAO).

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2

delta-Valerobetaine-d9 chloride

2 Cited Publications

Cat. No.: HY-114202S

CAS No.: 85806-18-4

Purity: ≥98.0%

delta-Valerobetaine-d₉ chloride is the deuterium labeled delta-Valerobetaine (HY-114202) . delta-Valerobetaine is a precursor of trimethylamine N-oxide (TMAO) .

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1

Trimethylamine N-oxide-d9

1 Cited Publications

Cat. No.: HY-116084S

CAS No.: 1161070-49-0

Purity: 99.76%

Trimethylamine N-oxide-d₉ is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

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1

Polymyxin B1

1 Cited Publications

Cat. No.: HY-A0248A

CAS No.: 4135-11-9

Category:

Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:

Bacterial

Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

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