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30 Results for "

trypanosome

" in MedChemExpress (MCE) Product Catalog:

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Diminazene aceturate

15 Publications Verification

Cat. No.: HY-12404

CAS No.: 908-54-3

Purity: 99.16%

Synonyms: Diminazene diaceturate

Target:

Parasite Angiotensin-converting Enzyme (ACE)

Research Areas:

Infection Inflammation/Immunology

Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties .

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Dihydroergotamine mesylate

6 Cited Publications

Cat. No.: HY-B0670A

CAS No.: 6190-39-2

Target:

Adrenergic Receptor 5-HT Receptor Dopamine Receptor Parasite

Dihydroergotamine mesylate is a blood-brain barrier-permeable semi-synthetic ergot alkaloid, acting as a full agonist of 5-HT1B/1D receptors (K_i values of 0.3 nM and 2.5 nM, respectively; functional IC₅₀ values of 2 nM and 2.2 nM, respectively). Dihydroergotamine mesylate inhibits Forskolin (HY-15371)-stimulated cAMP accumulation, possesses α-adrenergic receptor antagonistic activity and weak dopaminergic agonistic activity. It mediates intracranial cerebrovascular contraction, inhibits the release of neuropeptides such as CGRP/substance P, and suppresses neurogenic inflammation by activating 5-HT1B/1D receptors in the trigeminovascular system. Dihydroergotamine mesylate binds to the catalytic site of Trypanosoma cruzi trypanothione reductase and exhibits trypanocidal activity in vitro. Dihydroergotamine mesylate can be used in studies related to migraine and trypanosome infections .

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