trypanosomiasis | MedChemExpress (MCE) Life Science Reagents

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Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

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Eflornithine hydrochloride hydrate

28 Publications Verification

Cat. No.: HY-B0744B

CAS No.: 96020-91-6

Synonyms: DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate

Target:

Research Areas:

Cancer

Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride hydrate is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women .

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28

Eflornithine hydrochloride

28 Publications Verification

Cat. No.: HY-B0744A

CAS No.: 68278-23-9

Synonyms: DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride

Target:

Research Areas:

Parasite Fungal Phosphatase Bacterial Antibiotic

Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

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10

Pentamidine

10 Cited Publications

Cat. No.: HY-B0537

CAS No.: 100-33-4

Synonyms: MP-601205

Target:

Research Areas:

Parasite Fungal Phosphatase Bacterial Antibiotic

Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

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10

Pentamidine isethionate

10 Cited Publications

Cat. No.: HY-B0537B

CAS No.: 140-64-7

Synonyms: MP-601205 isethionate

Target:

Research Areas:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

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5

L-Anserine nitrate

5 Cited Publications

Cat. No.: HY-W011393

CAS No.: 10030-52-1

Category:

Target:

Endogenous Metabolite Parasite

L-Anserine nitrate is a naturally occurring histidine-containing dipeptide that is found in vertebrate skeletal muscle and animal tissues. L-Anserine nitrate serves as a growth-promoting supplement in serum-free HMI-244 medium for bloodstream forms of Trypanosoma brucei and Trypanosoma evansi. L-Anserine nitrate supports the continuous in vitro proliferation of these parasites, and the proliferated parasites retain their morphological characteristics and infectivity to mice. L-Anserine nitrate can be used in studies of African trypanosomiasis .

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3

Tryptophol

3 Cited Publications

Cat. No.: HY-W010155

CAS No.: 526-55-6

Synonyms: Indole-3-ethanol

Category:

Human Gut Microbiota Metabolites Natural Products Microorganisms Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Apoptosis Caspase Bacterial

Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy .

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3

Acoziborole

3 Cited Publications

Cat. No.: HY-19910

CAS No.: 1266084-51-8

Synonyms: SCYX-7158; AN5568

Target:

Research Areas:

DNA/RNA Synthesis Parasite

Acoziborole (SCYX-7158) is an effective, safe and orally active antiprotozoal agent for the research of human african trypanosomiasis (HAT). In the T. b. brucei S427 strain, the MIC value for SCYX-7158 is 0.6 μg/mL .

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1

DDD85646

1 Cited Publications

Cat. No.: HY-103056

CAS No.: 1215010-55-1

Purity: 99.72%

Synonyms: IMP-366

Target:

Research Areas:

Infection Neurological Disease

DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC₅₀=2 nM; hNMT IC₅₀=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .

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1

Pafuramidine

1 Cited Publications

Cat. No.: HY-14932

CAS No.: 186953-56-0

Purity: 99.28%

Synonyms: DB289

Target:

Parasite Antibiotic

Research Areas:

Pafuramidine (DB289) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria .

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Ebsulfur

Cat. No.: HY-128170

CAS No.: 2527-03-9

Purity: 98.71%

Target:

Research Areas:

Alkaloids Microorganisms Quinoline Alkaloids

Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC₅₀ values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis .

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Aurachin D

Cat. No.: HY-N7151

CAS No.: 108354-13-8

Category:

Target:

Antibiotic Bacterial Fungal

Aurachin D is an antibiotic and selective cytochrome bd oxidase inhibitor. Aurachin D exhibits inhibitory effects against Gram-positive bacteria and a small number of fungi, with an IC₅₀ value of 0.1 μM against Escherichia coli and an IC₅₀ value ranging from 0.13 to 33 μM against Mycobacterium tuberculosis. Aurachin D binds to and inhibits cytochrome bd oxidase, thereby blocking the electron transfer process, disrupting the respiratory chain and energy metabolism of pathogens. Aurachin D can be used in research related to leishmaniasis, malaria, Chagas disease, African trypanosomiasis, and tuberculosis [2] .

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NMT-IN-1

Cat. No.: HY-153021

CAS No.: 326879-46-3

Purity: ≥98.0%

Target:

Research Areas:

NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase (TbNMT) inhibitor, with an IC₅₀ of 31 μM against TbNMT and an IC₅₀ of 66 μM against hNMT. As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability .

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GNF6702

Cat. No.: HY-120060

CAS No.: 1799329-72-8

Purity: 98.48%

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